gastric cancer

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Hereditary diffuse gastric cancer: updated clinical practice guidelines

SOX2 is a functional marker of gastric cancer stem-like cells sensitive to monensin

Gastric cancer remains one of the most incident and deadly worldwide. It is usually detected in more advanced stages and therefore, the available treatments are not always sufficient to treat patients, leading to a low survival rate. Additionally, in some cases after an apparently successful treatment the cancer recurs. The recognition of cancer stem cells (CSCs) as keys of the tumorigenic process, metastasis and resistance to radio- and chemotherapy makes them an essential target for an efficient cancer treatment.

O-glycan truncation enhances cancer-related functions of CD44 in gastric cancer

CD44 isoforms are often upregulated in gastric cancer and have been associated with increased metastatic potential and poor survival. To evaluate the functional impact of O-glycan truncation on CD44 we have analysed glycoengineered cancer cell models displaying shortened O-glycans. Here, we demonstrate that induction of aberrant O-glycan termination through various molecular mechanisms affects CD44 molecular features.

Molecular weight of hyaluronic acid influences its interaction with gastric cancer cells through the CD44 receptor

Hyaluronic acid or hyaluronan is a biopolymer that accumulates in tumor microenvironments and around cancer cells. The accumulation is concomitant with changes of hyaluronan properties resulting in the generation of chains with different sizes. In this study, we mimic this peculiar tumor microenvironment and studied the response of gastric cancer cells. We selected two types of cells: AGS that have low expression of CD44 – a specific cellular receptor that recognize the hyaluronan and MKN45 with high CD44 expression.

O-glycans truncation modulates gastric cancer cell signaling and transcription leading to a more aggressive phenotype

Neste estudo foi possível identificar o papel de alterações de glicosilação específicas no comportamento de células de cancro gástrico e como estas contribuem para a progressão tumoral levando a um pior prognóstico dos pacientes. Era já conhecido que as células malignas apresentam alterações de expressão de glicanos com estrutura truncada. Nomeadamente, pacientes com cancro gástrico revelam ter um aumento de glicanos truncados, como por exemplo o Sialyl-Tn.

The Transcriptomic Landscape of Gastric Cancer: Insights into Epstein-Barr Virus Infected and Microsatellite Unstable Tumors

Authors and Affiliations:

Irene Gullo1,2,3,4, Joana Carvalho3,4, Diana Martins3,4, Diana Lemos3,4, Ana Rita Monteiro3,4, Marta Ferreira3,4, Kakoli Das5, Patrick Tan5,6,7, Carla Oliveira3,4, Fátima Carneiro1,2,3,4, Patrícia Oliveira3,4


1 Department of Pathology, Centro Hospitalar de São João, Porto, Portugal

New insights into the inflamed tumor immune microenvironment of gastric cancer with lymphoid stroma: from morphology and digital analysis to gene expression

Authors and Affiliations:

Irene Gullo1,2,3,4, Patrícia Oliveira3,4, Maria Athelogou5, Gilza Gonçalves2,3,4,6, Marta L Pinto4,7,8, Joana Carvalho3,4, Ana Valente3,4, Hugo Pinheiro3,4,9, Sara Andrade3,4,10, Gabriela M. Almeida3,4, Ralf Huss5, Kakoli Das11, Patrick Tan11,12,13, José C. Machado2,3,4, Carla Oliveira2,3,4, Fátima Carneiro1,2,3,4


New molecular mechanism to explain cases of hereditary gastric cancer

The most common cause of Hereditary Diffuse Gastric Cancer are germline mutations of the CDH1 gene. The vast majority of CDH1 germline alterations lead to truncated forms of E-cadherin with loss of protein function.

The various faces of hereditary diffuse gastric cancer

Gastric cancer: Beyond Helicobacter pylori infection

Gastric cancer is one of the most incident and deadly in the world. Helicobacter pylori infection plays a key role in the early stages of the process leading to the development of cancer. In this study, the authors show that there is a shift in the profile of the gastric microbiome from patients with chronic gastritis to patients with gastric cancer. The gastric microbiome of cancer patients is dysbiotic, presenting reduced microbial diversity, decreased abundance of H. pylori, and increased abundance of other species of bacteria.