gastric cancer

Authors and affiliations:
Ramon Andrade de Mello, MD, PhD ,1 - Serviço de Oncologia Médica - IPO do Porto 2 - Departamento de Medicina, Faculdade de Medicina da Universidade do Porto, Porto 3 - Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, Faro

The Coimbra Genomics S.A., a company dedicated to the emergent field of genomics, jointly with IPATIMUP and the Chinese organization BGI are lauching a research project aiming to understand the genetic basis of gastric carcinoma.

Authors and affiliations:

Ricardo Marcos-Pinto^1,2,3,4, Mário Dinis-Ribeiro^4,6, Fátima Carneiro^3,5, Xiaogang Wen⁵, Carlos Lopes^7,1, Céu Figueiredo^3,5, José Carlos Machado^3,5, Rui Ferreira³, Celso A. Reis^1,3,5, José Ferreira², Isabel Pedroto^1,2, Jorge Areias^1,2

1. Institute of Biomedical Sciences, University of Porto (ICBAS/UP), Porto, Portugal

Authors and affiliations:

Salomé S. Pinho1,2, Sandra Carvalho1,2, Ricardo Marcos-Pinto2,3, Ana Magalhaes1, Carla Oliveira1,4, Jianguo Gu5, Mário Dinis-Ribeiro6,7, Fátima Carneiro1,4,8, Raquel Seruca1,4, and Celso A. Reis1,2,4

1 Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Dr Roberto Frias s/n, 4200-465 Porto, Portugal

2 Institute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira n.8 228, 4050-313 Porto, Portugal

O cancro gástrico apresenta uma alta incidência e mortalidade, sendo necessário compreender os mecanismos moleculares subjacentes, a fim de descobrir novos biomarcadores com utilidade clinica. Este artigo de revisão resume o papel dos glicanos a as alterações da glicosilação ao longo do processo de desenvolvimento e progressão do cancro gástrico. São discutidos neste artigo as aplicações clínicas destas alterações de glicosilação. Na foto, Salomé Pinho e Celso A. Reis, investigadores do IPATIMUP.

Autores e afiliações:

The study identified proteins with abnormal glycosylation in the serum of patients with pre-neoplastic gastric lesions, indicating the possibility of non-invasive diagnosis in this context. The serum glycoproteome approach identified, among others, plasminogen as a carrier of aberrant glycoforms.

Journal:
Journal of Proteome Research

Salomé Pinho was awarded with the «Young Investigator Award» by the EACR for her contribution for the identification of a novel regulatory system of a protein that is determinant in the process of gastric cancer development and progression.

This work was recently published in Biochimica et Biophysica Acta (Pinho SS et al BBA 2012 [Epub ahead of print]) and PLoS ONE (Pinho SS et al. PLoS One. 2012;7(3):e33191) journals.

Abstract

Salomé Pinho was awarded with the “Young Investigator Award” by the EACR for her contribution for the identification of a novel regulatory system of a protein that is determinant in the process of gastric cancer development and progression.

This work was recently published in Biochimica et Biophysica Acta (Pinho SS et al BBA 2012 [Epub ahead of print]) and PLoS ONE (Pinho SS et al. PLoS One. 2012;7(3):e33191) journals.

Abstract