gastric cancer

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Desregulação da p53 nos carcinomas gástricos associados ao EBV

O cancro gástrico é a quinta neoplasia mais frequente em todo o mundo, sendo a terceira causa de morte por cancro. Na década de 90, o vírus de Epstein-Barr (EBV) foi pela primeira vez detetado em amostras de carcinoma do estômago e desde então tem sido associado a cerca de 10% de todas estas neoplasias. Nos últimos anos, um grupo de investigadores do IPO-Porto tem-se dedicado ao estudo dos carcinomas gástricos associados à infeção por EBV.

Dies1/VISTA expression loss is a recurrent event in gastric cancer due to epigenetic regulation

Authors and Affiliations:

Oliveira P1,2, Carvalho J1,2, Rocha S1,2, Azevedo M2, Reis I2, Camilo V2, Sousa B1,2, Valente S1,2, Paredes J1,2,3, Almeida R1,2,3, Huntsman D4, Oliveira C1,2,3.

Dies1/VISTA expression loss is a recurrent event in gastric cancer due to epigenetic regulation

Autores e Afiliações:

Oliveira P1,2, Carvalho J1,2, Rocha S1,2, Azevedo M2, Reis I2, Camilo V2, Sousa B1,2, Valente S1,2, Paredes J1,2,3, Almeida R1,2,3, Huntsman D4, Oliveira C1,2,3.

O–mannosylation and N-glycosylation: two coordinated mechanisms regulating the tumour suppressor functions of E-cadherin in cancer

Gastric cancer mortality and prevalence of Helicobacter pylori infection in Portugal

The consistently high prevalence of Helicobacter pylori infection observed across age groups and studies carried out in different periods shows a large potential for decrease in the burden of gastric cancer in Portugal, and the downward trends in mortality rates may be expected to remain in the next decades.

 

 

Authors and affiliations:

Samantha Morais1, Ana Ferro1, Ana Bastos1, Clara Castro1,2, Nuno Lunet1,3, Bárbara Peleteiro1,3

E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade

Authors and Affiliations:
Caldeira J 1*, Figueiredo J 2*, Brás-Pereira C 3, Carneiro P 2, Moreira AM 2, Pinto MT 2, Relvas JB 4, Carneiro F 5, Barbosa M 6, Casares F 7, Janody F 3, Seruca R 8.
*The authours contributed equally

Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer

Helicobacter pylori modulates the gastric mucosa glycosylation for long term-colonization

Probing the O-glycoproteome of Gastric Cancer Cell Lines for Biomarker Discovery

Authors and Affiliations:

Diana Campos1,2, Daniela Freitas2, Joana Gomes2, Ana Magalhães2, Catharina Steentoft1, Catarina Gomes2, Malene B. Vester-Christensen1*, José Alexandre Ferreira3,4, Luis P. Afonso5, Lúcio L. Santos3, João Pinto de Sousa6, Ulla Mandel1, Henrik Clausen1, Sergey Y. Vakhrushev1, Celso A. Reis2,6,7

Worldwide Burden of Gastric Cancer Attributable to Tobacco


Bárbara Peleteiro1,2, Clara Castro1,3, Samantha Morais1, Ana Ferro1, Nuno Lunet1,2 1 EPIUnit – Institute of Public Health, University of Porto, Porto, Portugal 2 Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal 3 North Region Cancer Registry (RORENO) – Portuguese Oncology Institute, Porto, Portugal