gastric cancer

Authors and Affiliations:

Carla Oliveira*, Hugo Pinheiro*, Joana Figueiredo, Raquel Seruca, Fátima Carneiro

Ipatimup-Institute of Molecular Pathology and Immunology & Instituto Instituto de Investigação e Inovação em Saúde,

(C Oliveira PhD, H Pinheiro PhD, J Figueiredo PhD, R Seruca MD, Prof F Carneiro MD), and

Department of Pathology and Oncology, Faculty of Medicine (C Oliveira, R Seruca, F Carneiro),

University of Porto, Porto, Portugal; and Centro Hospitalar S João, Porto, Portugal (F Carneiro)

Autores e Afiliações:

Carla Oliveira*, Hugo Pinheiro*, Joana Figueiredo, Raquel Seruca, Fátima Carneiro

Ipatimup-Institute of Molecular Pathology and Immunology & Instituto Instituto de Investigação e Inovação em Saúde,

(C Oliveira PhD, H Pinheiro PhD, J Figueiredo PhD, R Seruca MD, Prof F Carneiro MD), and

Department of Pathology and Oncology, Faculty of Medicine (C Oliveira, R Seruca, F Carneiro),

University of Porto, Porto, Portugal; and Centro Hospitalar S João, Porto, Portugal (F Carneiro)

Authors and Affiliations:

João Miguel Sanches¹, Joana Figueiredo², Martina Fonseca¹, Cecília Durães², Soraia Melo², Sofia Esménio¹ and Raquel Seruca ^2,3

Authors and Affiliations:

Ana Sadio ¹,^2,3,4,5, Jenny K. Gustafsson ⁶, Bruno Pereira ¹, Carla Pereira Gomes ^2,7, Gunnar C. Hansson ⁶, Leonor David ^1,5, Ana Paula Pêgo ^2,7,8, Raquel Almeida ^1,5*

¹ IPATIMUP- Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal,

² INEB – Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal,

Authors and affiliations:
Ana Ferro 1, Bárbara Peleteiro 1,2, Matteo Malvezzi 3, Cristina Bosetti 3, Paola Bertuccio 3, Fabio Levi 4, Eva Negri 3, Carlo La Vecchia 3,5 , Nuno Lunet 1,3 1-Institute of Public Health of the University of Porto (ISPUP), Rua das Taipas nº 135, 4050-600 Porto, Portugal

2-Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

This study is part of the EUR-GAST Project, established to elucidate the effects of Helicobacter pylori infection, genetic polymorphisms and environmental factors in gastric cancer etiology in European populations. The EUR-GAST Project is enclosed in a much larger European investigation (European Prospective Investigation into Cancer and Nutrition – EPIC) which is designed to investigate the relationships between diet, nutritional status, lifestyle and environmental factors and the incidence of cancer and other chronic diseases.

Escola de Ciências da Vida e da Saúde da Universidade do Minho - Campus de Gualtar - Anfiteatro A1 - Braga, Portugal

27-28 March, 2014

See more informations here: http://www.gastriccancerbraga2014.com/

Gastric cancer is one of the most prevalent and fatal in the world, especially due to its invasive nature, and the capacity to metastasize at distance, frequently without symptoms. E-cadherin is one of the most important structural molecules in the stomach, and its expression in the gastric epithelia suppresses cancer development. Carriers of mutations in the gene encoding E-cadherin have high probability of developing hereditary diffuse gastric cancer. Strategies aiming to prevent the loss of E-cadherin expression enclose high therapeutic potential for gastric cancer.