Patrícia Mesquita

Researchers from the "Differentiation and Cancer" group at i3S, in collaboration with “Cancer Metastasis” and “Cell Division & Genomic Stability” groups and Carmen Jerónimo from IPO-Porto, elucidated the role of YTHDF3, a key m6A RNA “reader” protein, as a driver of gastric cancer (GC) progression and paclitaxel sensitivity. This new study, entitled "The RNA‑binding protein YTHDF3 affects gastric cancer cell migration and response to paclitaxel by regulating EZRIN," was recently published in the journal "Gastric Cancer”.

Investigadores do grupo “Differentiation and Cancer” do i3S, em colaboração com os grupos “Cancer Metastasis” e “Cell Division & Genomic Stability” e a Prof. Carmen Jerónimo do IPO-Porto, elucidaram o papel da YTHDF3, uma proteína chave que faz a "leitura" do RNA modificado com N6-metiladenosina (m6A), na progressão do cancro gástrico (GC) e da sensibilidade ao paclitaxel.

Researchers from the "Differentiation and Cancer" group at i3S, in collaboration with António Pombinho, from the "BioSciences Screening" platform, and Filipe Pereira, from Lund University, elucidated the role of the transcription factor HMGA1 in gastric cancer stem cells. The study, entitled "HMGA1 stimulates cancer stem-like features and sensitivity to monensin in gastric cancer," was recently published in the journal "Experimental Cell Research."

Investigadores do grupo “Diferenciação e Cancro” do i3S, em colaboração com António Pombinho, da plataforma “BioSciences Screening”, e Filipe Pereira, da Universidade de Lund, elucidaram o papel do fator de transcrição HMGA1 nas células estaminais de cancro gástrico. O estudo, intitulado “HMGA1 stimulates cancer stem-like features and sensitivity to monensin in gastric cancer”, foi recentemente publicado na revista “Experimental Cell Research”.