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CRUK Beatson Institute Workshop: Understanding Tumour Immunology

Cancer Research UK Beatson Institute, Glasgow, United Kingdom

 

03 - 04 September, 2017

 

See more informations here: http://www.beatson.gla.ac.uk/Beatson-Workshop/beatson-workshop.html

CRUK Beatson Institute Workshop: Understanding Tumour Immunology

Cancer Research UK Beatson Institute, Glasgow, United Kingdom

 

03 - 04 September, 2017

 

See more informations here: http://www.beatson.gla.ac.uk/Beatson-Workshop/beatson-workshop.html

Actin stress fibers-mediated cell stiffening promotes the proliferation of pre-invasive breast cancer cells

In this study recently published in Nature Communications, the authors use a human breast cell line with conditional Src induction, breast tumor lesions and the in vivo model Drosophila melanogaster to show that cells undergo an actin stress fiber-mediated cell stiffening state prior to acquiring malignant features. This state promotes ERK-dependent cell proliferation, as well as, the progression towards a fully transformed state.

Enrijecimento celular mediado por fibras de actina promove a proliferação de células cancerígenas

Neste estudo, recentemente publicado na revista Nature Communications, os autores usam uma linha celular mamária com indução condicional de Src, tumores mamários e o modelo animal Drosophila melanogaster, para mostrar que as células sofrem um enrijecimento dependente da acumulação de stress-fibers, antes de adquirirem características malignas. Este estado promove a proliferação celular dependente de ERK, assim como a progressão até ao estado de completa transformação.

3rd International Symposium Innovations in Oncology: How to Eliminate Colon Cancer – A Road Map

German Cancer Research Center (DKFZ), Heidelberg, Germany

 

26 - 27 June, 2017

 

See more informations here: https://www.nct-heidelberg.de/das-nct/veranstaltungen/innovations-in-oncology.html

 

3rd International Symposium Innovations in Oncology: How to Eliminate Colon Cancer – A Road Map

German Cancer Research Center (DKFZ), Heidelberg, Germany

 

26 - 27 June, 2017

 

See more informations here: https://www.nct-heidelberg.de/das-nct/veranstaltungen/innovations-in-oncology.html

 

OECI Oncology Days 2017

Hotel International, Brno, Czech Republic

 

21-23 June, 2017

 

See more informations here: https://www.eacr.org/user_uploads/files/OECI_BRNO%202017.2nd.Ann..pdf

 

 

OECI Oncology Days 2017

Hotel International, Brno, Czech Republic

 

21-23 June, 2017

 

See more informations here: https://www.eacr.org/user_uploads/files/OECI_BRNO%202017.2nd.Ann..pdf

 

 

Liquid Biopsies & Cancer

University of Leuven (Leuven, Belgium)

 

28-30 August, 2017

See more informations here: https://kuleuvencongres.be/LKI2017
 

Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression

In this study, the authors combined the use of genome editing tools and last generation inducible systems in order to develop a cell model where the expression of CDX2 transcription factor can be tightly regulated. CDX2 is an intestinal differentiation marker whose expression is often altered in gastric and colon carcinomas. Its control was here shown to be useful to uncover novel putative downstream effector genes (such as GPA33 and LDLR), and therefore, to further clarify the role of CDX2 in intestinal cells.