In this study, the authors combined the use of genome editing tools and last generation inducible systems in order to develop a cell model where the expression of CDX2 transcription factor can be tightly regulated. CDX2 is an intestinal differentiation marker whose expression is often altered in gastric and colon carcinomas. Its control was here shown to be useful to uncover novel putative downstream effector genes (such as GPA33 and LDLR), and therefore, to further clarify the role of CDX2 in intestinal cells.
