colon cancer

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Targeting ERK5 in colon cancer stem-like cells

A research team led by Cecília Rodrigues, from the Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, has identified a new molecular pathway underlying the maintenance of stem cell-like features in colon cancer cells. This study was published in Cell Death Discovery. The presence of cancer stem cells within tumors, including those from the colon and rectum, is associated with increased therapy resistance and worse clinical outcomes.

3rd International Symposium Innovations in Oncology: How to Eliminate Colon Cancer – A Road Map

German Cancer Research Center (DKFZ), Heidelberg, Germany

 

26 - 27 June, 2017

 

See more informations here: https://www.nct-heidelberg.de/das-nct/veranstaltungen/innovations-in-oncology.html

 

3rd International Symposium Innovations in Oncology: How to Eliminate Colon Cancer – A Road Map

German Cancer Research Center (DKFZ), Heidelberg, Germany

 

26 - 27 June, 2017

 

See more informations here: https://www.nct-heidelberg.de/das-nct/veranstaltungen/innovations-in-oncology.html

 

Nanoformulations of a potent copper-based aquaporin inhibitor with cytotoxic effect against cancer cells

Authors and Affiliations:

Mariana Navea, Rui E. Castroa, Cecília M. P. Rodriguesa, Angela Casinib, Graça Soverala, M. Manuela Gaspara

a Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal

b School of Chemistry, Cardiff University, Park Place, Cardiff CF 10 3AT, United Kingdom

 

Abstract:

MEK5-ERK5 signaling contributes to the progression of colon cancer


AES Simões1, DM Pereira1, SE Gomes1, H Brito1, T Carvalho2, A French3, RE Castro1, CJ Steer4,5, SN Thibodeau3, CMP Rodrigues*,1,6 and PM Borralho*,1,6

1 Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisbon 1649-003, Portugal;