Colorectal cancer

Authors and Affiliations:

Maria Sofia Fernandes^1,2, Soraia Melo^1,2,3, Sérgia Velho^1,2, Patrícia Carneiro^1,2, Fátima Carneiro^1,2,3,4, Raquel Seruca^1,2,3

RAI Amsterdam, Forum Centre, Amsterdam, Netherlands

11 - 13 December, 2016

See more informations here: http://www.emccc2016.org/en/Home_10_6_12.html

RAI Amsterdam, Forum Centre, Amsterdam, Netherlands

11 - 13 December, 2016

See more informations here: http://www.emccc2016.org/en/Home_10_6_12.html

Authors and Affiliations:

Paulo Matos (1-3), Vânia Gonçalves (2,3), Peter Jordan (2,3)

1. Department of Chemistry and Biochemistry, Faculty of Sciences, University of Lisbon, Portugal

2. BioISI — Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, Portugal

3. Department of Human Genetics, National Health Institute ‘Dr. Ricardo Jorge’, Lisbon, Portugal

Abstract:

RAI, Amsterdam, Netherlands

11 - 13 December, 2016

See more informations here: http://www.emccc2016.org/en/Home_10_6_12.html

RAI, Amsterdam, Netherlands

11 - 13 December, 2016

See more informations here: http://www.emccc2016.org/en/Home_10_6_12.html

O recente interesse para modular a autofagia na terapêutica do cancro tem sido dificultado pelo papel duplo deste processo catabólico no cancro, destacando a necessidade de abordagens personalizadas. Uma vez que as isoformas do RAS têm sido implicadas na regulação da autofagia e a mutação do oncogene KRAS é muito frequente no cancro colorretal (CCR), questionamos se/como os alelos mutados do KRAS regulam a autofagia no CCR e quais as suas implicações.

Tumour initiation results from a mutation acquired, for example, in a cell proliferation-regulating oncogene, for example the MAP kinase BRAF in melanoma, thyroid, ovarian and colorectal cancer. As a protective response to this initial proliferative stimulus, tissues induce a growth-arrest program termed oncogene-induced senescence (OIS). It remains largely unknown by which mechanisms the initiated cells eventually escape from the dormant OIS state.

Authors and Affiliations:

Cláudia Suellen F. Oliveira (1,2), Helena Pereira (1), Sara Alves (1), Lisandra Castro (1), Fátima Baltazar (3,4), Susana R. Chaves (1), Ana Preto (1*), Manuela Côrte-Real (1*#)

(1) CBMA- Centro de Biologia Molecular e Ambiental. Departamento de Biologia, Universidade do Minho, Campus de Gualtar, 4710-057, Braga, Portugal.

(2) ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313, Porto, Portugal.