Colorectal cancer

Authors and Affiliations:

Ricardo Amorim^a,b, Céline Pinheiro^a,b,c,d, Vera Miranda-Gonçalves^a,b, Helena Pereira^e,

Mary P. Moyer^f, Ana Preto^e, Fátima Baltazar^a,b

^a Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal

^b ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal

In light of recent findings on the association between insulin resistance and the development of colorectal malignancies, it is worthwhile to investigate whether metabolic syndrome (MS) is correlated to an increased number of colorectal neoplasms. However, few studies have been performed regarding the relationship between MS, colorectal adenomatous polyps, and cancer in Western or European countries. With this study, we aimed to investigate the association between MS and colorectal neoplasms in a Portuguese population.

Researcher Noel Miranda, who has focused his work in the treatment of colorectal cancer, was honored by the American Association for Cancer Research (AACR) with a grant of 93 thousand euros. Currently doing research at the Medical Center of the Leiden University (Netherlands), this 32 year old researcher now has the opportunity to pursue studies in this area and establish his own research group in the future.

Heidelberg, Germany

5- 6 June, 2014

See more informations here: http://www.ci-3.de/sites/default/files/field_event_file/innovationsworkshop2014_0.pdf

Heidelberg, Germany

5- 6 June, 2014

See more informations here: http://www.ci-3.de/sites/default/files/field_event_file/innovationsworkshop2014_0.pdf

This work follows the one published in 2010 by Sérgia Velho from Professor Raquel Seruca’s group at IPATIMUP, in which MLK3 mutations were for the first described to occur in gastric and colorectal cancers. These mutations were associated with the induction of invasive potential of cancer cells. In the present work, the authors performed expression microarray analysis in order to determine the signaling pathways underlying the oncogenic properties of mutant MLK3.

Authors and affiliations:

O cancro colorectal (CRC) é uma das principais causas de morte associada a cancro em todo o Mundo. Para o estabelecimento do CRC as células intestinais sofrem uma acumulação de alterações genéticas e epigenéticas em vários oncogenes e genes supressores tumorais. Um dos exemplos de genes supressores tumorais envolvidos no processo de cancerização é a familia RASSF.