It was published an updated critical literature review on human and yeast RAS pathways, specifically highlighting the similarities and differences between them. Moreover, it was also adressed the contribution of studying yeast RAS pathways for the understanding of human RAS and how this model organism can contribute to unveil the roles of RAS oncoproteins in the regulation of mechanisms important in the tumorigenic process, like autophagy.
Functionalized nanoparticles have been explored for cancer treatment, as a mean to efficiently deliver the anti-cancer drugs to tumor-site, improving the outcome of those molecules. In this work, polymericpoly(lactic-co-glycolic)-polyethyleneglicol (PLGA-PEG) nanoparticles were produced and surface-functionalized with an antibody targeting the Carcinoembryonic Antigen (CEA) of intestinal epithelial cells. CEA is overexpressed in several cancers, including colorectal cancer. Nanoparticles were loaded with paclitaxel (PTX), an anticancer drug.
It was published a review article that covers the current knowledge on the transport of short chain fatty acids by colorectal cancer cells and their effects on colorectal cancer metabolism and survival. It is also adressed the impact of increasing short chain fatty acids production by manipulation of colon microbiota on the prevention and therapy of this disease.
It was published a review article that covers the current knowledge on the transport of short chain fatty acids by colorectal cancer cells and their effects on colorectal cancer metabolism and survival. It is also adressed the impact of increasing short chain fatty acids production by manipulation of colon microbiota on the prevention and therapy of this disease.
Colorectal cancer (CRC) is one of the major causes of morbidity and mortality throughout the world. The etiological factors and pathogenic mechanisms underlying CRC development appear to be complex and heterogeneous. The majority of CRC cases occur sporadically, arising through the sequential accumulation of multiple genetic and/or epigenetic alterations involving genes that regulate cell growth and differentiation.
O cancro colo-retal (CCR) é uma das principais causas de morbilidade e mortalidade em todo o mundo. Os fatores etiológicos e mecanismos patogénicos subjacentes ao desenvolvimento do CCR são complexos e heterogéneos. A maioria dos casos de CCR ocorrem esporadicamente, surgindo através da acumulação sequencial de várias alterações genéticas e/ou epigenéticas envolvendo genes que regulam o crescimento e diferenciação celular. Apesar dos avanços na compreensão das vias de carcinogénese do CCR esporádico, o significado destas alterações ainda não está completamente compreendido.
The inflammatory status interferes with the cellular uptake of butyrate and folic acid, two nutrients with a role in colorectal cancer pathogenesis, by intestinal epitelial cells. The anti-inflammatory acetylsalicylic acid potentiates the anticarcinogenic effect of BT in Caco-2 cells by increasing its cellular uptake.
Mafalda R. Couto, M.D.1#, Pedro Gonçalves, Ph.D.1, 2#, Telmo A. Catarino, B.Sc.1, Fátima Martel, Ph.D.1
The inflammatory status interferes with the cellular uptake of butyrate and folic acid, two nutrients with a role in colorectal cancer pathogenesis, by intestinal epitelial cells. The anti-inflammatory acetylsalicylic acid potentiates the anticarcinogenic effect of BT in Caco-2 cells by increasing its cellular uptake.
Mafalda R. Couto, M.D.1#, Pedro Gonçalves, Ph.D.1, 2#, Telmo A. Catarino, B.Sc.1, Fátima Martel, Ph.D.1
