glycosylation

envie a um amigo share this

Multicellular Human Gastric Cancer Spheroids Mimic the Glycosylation Phenotype of Gastric Carcinomas

3-dimensional (3D) systems mimic better the in vivo features of the tumor, however, the in vitro studies of cancer have been traditionally performed using 2D methods. In this study, published in the journal Molecules, a high-throughput 3D methodology has been established for four different gastric cancer cell lines. These cancer models have been fully characterised, focusing on the glycosylation profile, since it is known that changes in glycosylation are key players in cancer development and progression.

Extracellular Vesicles from Ovarian Carcinoma Cells Display Specific Glycosignatures

Joana Gomes 1, Patrícia Gomes-Alves 1,2, Sofia B. Carvalho 1,2, Cristina Peixoto 1,2, Paula M. Alves 1,2, Peter Altevogt 3,4 and Julia Costa 1

1 Instituto de Tecnologia Quimica e Biologica Antonio Xavier, Universidade Nova de Lisboa Av. da Republica, Oeiras 2780-157, Portugal

2 iBET, Instituto de Biologia Experimental e Tecnologica, Oeiras 2780-157, Portugal

Helicobacter pylori modulates the gastric mucosa glycosylation for long term-colonization

Gastric Cancer: adding glycosylation to the equation

Authors and affiliations:

Salomé S. Pinho1,2, Sandra Carvalho1,2, Ricardo Marcos-Pinto2,3, Ana Magalhaes1, Carla Oliveira1,4, Jianguo Gu5, Mário Dinis-Ribeiro6,7, Fátima Carneiro1,4,8, Raquel Seruca1,4, and Celso A. Reis1,2,4

1 Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Dr Roberto Frias s/n, 4200-465 Porto, Portugal

2 Institute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira n.8 228, 4050-313 Porto, Portugal

Gastric Cancer: adding glycosylation to the equation

O cancro gástrico apresenta uma alta incidência e mortalidade, sendo necessário compreender os mecanismos moleculares subjacentes, a fim de descobrir novos biomarcadores com utilidade clinica. Este artigo de revisão resume o papel dos glicanos a as alterações da glicosilação ao longo do processo de desenvolvimento e progressão do cancro gástrico. São discutidos neste artigo as aplicações clínicas destas alterações de glicosilação. Na foto, Salomé Pinho e Celso A. Reis, investigadores do IPATIMUP.

 

 

Autores e afiliações: