Autophagy is a catabolic process which targets cellular organelles and cytoplasmic constituents to the lysosomes for degradation, allowing the cell to maintain homeostasis and being particularly relevant during nutrient deprivation and other stresses.
A autofagia é um processo catabólico através do qual organelos celulares e constituintes do citoplasma são sinalizados para degradação no lisossoma, permitindo manter a homeostasia celular e sendo particularmente relevante em situações de falta de nutrientes ou outros tipos de stress celular.
AS Ribeiro1,2, FA Carvalho3, J Figueiredo1,2, R Carvalho1, T Mestre4, J Monteiro1, AF Guedes3, M Fonseca4, J Sanches4, R Seruca1,2,5, NC Santos3, J Paredes1,2,5
1 i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal;
2 Institute of Molecular Pathology and Immunology of the University of Porto;
O reconhecimento das propriedades biomecânicas das células tumorais permite compreender os mecanismos físicos responsáveis pelo processo metastático. As Caderinas, que são moléculas que promovem a adesão célula-célula, desempenham um papel crucial durante a progressão tumoral. No entanto, na maioria dos estudos, não existem dados que liguem a sinalização pro-tumorigénica e as variações no equilíbrio mecânico mediado pelas forças de adesão promovidas pelas caderinas.
Treatment and management of breast cancer imposes a heavy burden on the public health care. However, in spite of the considerable advancements in the treatment of this malignancy in the recent years, many patients continue to progress to metastatic disease and, for those with advanced breast cancer, palliative care is oftentimes the endpoint. The manifestation of metastases is predictive of poor clinical outcome, and prevails one of the most challenging issues faced by cancer treatment today.
Treatment and management of breast cancer imposes a heavy burden on the public health care. However, in spite of the considerable advancements in the treatment of this malignancy in the recent years, many patients continue to progress to metastatic disease and, for those with advanced breast cancer, palliative care is oftentimes the endpoint. The manifestation of metastases is predictive of poor clinical outcome, and prevails one of the most challenging issues faced by cancer treatment today.
