murine model

Treatment and management of breast cancer imposes a heavy burden on the public health care. However, in spite of the considerable advancements in the treatment of this malignancy in the recent years, many patients continue to progress to metastatic disease and, for those with advanced breast cancer, palliative care is oftentimes the endpoint. The manifestation of metastases is predictive of poor clinical outcome, and prevails one of the most challenging issues faced by cancer treatment today.

Combined administration of Pd2Spm and Docetaxel trigger a substantial synergetic effect regarding angiogenesis inhibition, but also anti-migratory and anti-proliferative effects, reinforcing the putative use of metal based Paladium complex molecules in chemotherapeutic regimens.

Authors and Affiliations:

Ana L.M. Batista de Carvalho-Unidade de I&D Química-Física Molecular, Department of Chemistry, University of Coimbra, Portugal.

A administração combinada de Pd2Spm e Docetaxel desencadeia efeitos sinergéticos como antiangiogénico, mas também como anti-migratório e anti-proliferativo, mostrando o beneficio da utilização conjunta de moléculas complexas com base em metal de Paladio em regimes quimioterapêuticos.

Autores e Afiliações:

Ana L.M. Batista de Carvalho-Unidade de I&D Química-Física Molecular, Department of Chemistry, University of Coimbra, Portugal.