breast cancer

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Novel anti-DLL1 antibody with anti-tumor efficacy against breast cancer

Over 70% of breast cancers (BC) are estrogen receptor-positive (ER+). The Notch ligand Delta-like 1 (DLL1) is a key player in ER+ BCs development and aggressiveness and its overexpression are associated with poor prognosis. In this study, Portuguese researchers developed a novel anti-DLL1 antibody that inhibited tumor growth and liver metastases in a xenograft mouse model. The data suggests that anti-DLL1 immunotherapy can be a promising strategy for ER+ BC treatment.

 

Authors and Affiliations:

Novo anticorpo com propriedades anti-tumorais para cancro da mama

Mais de 70% dos cancros da mama são positivos para o recetor de estrogénio (ER+ BC). A expressão elevada da proteína DLL1 nestes tumores está associada a maior agressividade e por conseguinte a pior prognóstico. Neste estudo, investigadores portugueses desenvolveram um anticorpo capaz de impedir a formação de metástases hepáticas em modelos animais xenotransplantados. Este estudo sugere a inibição da proteína DLL1 como uma nova abordagem no tratamento de cancros da mama positivos para o recetor de estrogénio.

 

Autores e afiliações:

Innovation in Breast Cancer symposium – Lisbon edition

Virtual event

 

14-15 October, 2021

 

See more informations here: https://www.doctaforum.org/2021/ibc2021-lisbon/

Innovation in Breast Cancer symposium – Lisbon edition

Virtual event

 

14-15 October, 2021

 

See more informations here: https://www.doctaforum.org/2021/ibc2021-lisbon/

Natural killer cells put breast cancer to sleep

Even after apparently successful treatment of primary tumor, some undetectable tumor cells can persist and cause cancer to eventually come back. These cells spread beyond the primary tumor to other organs of the body, where they lay dormant until awakening into deadly metastases.

Unveiling the mechanism of action behind the anti-cancer properties of cannabinoids in ER+ breast cancer cells: Impact on aromatase and steroid receptors

Authors and Affiliations:

Cristina Amaral, Fabien Marc Trouille, Cristina Ferreira Almeida, Georgina Correia-da-Silva, Natércia Teixeira

UCIBIO.REQUIMTE, Laboratório de Bioquímica, Faculdade de Farmácia, Universidade do Porto

 

Abstract:

Unveiling the mechanism of action behind the anti-cancer properties of cannabinoids in ER+ breast cancer cells: Impact on aromatase and steroid receptors

Autores e Afiliações:

Cristina Amaral, Fabien Marc Trouille, Cristina Ferreira Almeida, Georgina Correia-da-Silva, Natércia Teixeira

UCIBIO.REQUIMTE, Laboratório de Bioquímica, Faculdade de Farmácia, Universidade do Porto

 

Abstract:

GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure

GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure

A Step forward in Breast Cancer Research: From a Natural-Like Experimental Model to a Preliminary Photothermal Approach



Eduardo Costa 1,2,3,4, Tânia Ferreira-Gonçalves 3, Miguel Cardoso 2,5,6,7, João M. P. Coelho 8, Maria Manuela Gaspar 3, Pedro Faísca 9, Lia Ascensão 10, António S. Cabrita 2, Catarina Pinto Reis 3,8,* and Isabel V. Figueiredo 1,7,*

1 Pharmacology and Pharmaceutical Care Laboratory, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal;