extracellular vesicles

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Chitinase 3-like-1 and fibronectin in the cargo of extracellular vesicles shed by human macrophages influence pancreatic cancer cellular response to gemcitabine

The work recently published in the journal “Cancer Letters” by Cristina Xavier et al., in the scope of her post-doctoral research at the Cancer Drug Resistance Group, i3S, demonstrated the impact of Extracellular Vesicles released by macrophages on the response of pancreatic cancer cells to a chemotherapeutic agent. This work results from a collaboration with the Tumor and Microenvironment Interactions Group of i3S, the Experimental Pathology and Therapeutics Group of IPO-Porto and the Genetic Diversity Group of i3S.

 

Authors and Affiliations:

Lung cancer bronchoalveolar lavage: proteome landscape of extracellular vesicles, a cue to diagnosis

Bronchoalveolar lavage is routinely collected during bronchoscopy for cytology analysis in the diagnostic of lung cancer. Due to low sensitivity of this method, early-stage cancers are undetected, lowering the treatment success. In this study, we analysed extracellular vesicles isolated from bronchoalveolar lavage of lung cancer suspects by mass spectrometry-based proteomics. The protein composition of bronchoalveolar lavage extracellular vesicles of late-stage cancer showed a higher proteome complexity associated with mortality within the two year follow-up period.

Lung cancer bronchoalveolar lavage: proteome landscape of extracellular vesicles, a cue to diagnosis

O lavado broncoalveolar é recolhido através de broncoscopia para análise citológica no diagnóstico de cancro do pulmão. Devido à baixa sensibilidade do método, os tumores em estadio inicial não são detetados, o que diminui o sucesso do tratamento. Neste estudo, analisámos por espectrometria de massa vesículas extracelulares isoladas a partir do lavado broncoalveolar de indivíduos suspeitos de cancro do pulmão.

Transcriptome Reprogramming of CD11b+ Bone Marrow Cells by Pancreatic Cancer Extracellular Vesicles


Joana Maia1,2, Andreia Hanada Otake1,3, Juliana Poças4,5,6, Ana Sofia Carvalho7, Hans Christian Beck8, Ana Magalhães4,5, Rune Matthiesen7, Maria Carolina Strano Moraes1 and Bruno Costa-Silva1

1-Champalimaud Centre for the Unknown, Champalimaud Foundation, Lisbon, Portugal

2-Graduate Program in Areas of Basic and Applied Biology, University of Porto, Porto, Portugal

Transcriptome Reprogramming of CD11b+ Bone Marrow Cells by Pancreatic Cancer Extracellular Vesicles

O cancro de pâncreas é a quarta principal causa de mortes relacionadas ao cancro no mundo, apresentando uma taxa de sobrevida de 5 anos de cerca de 6% e uma taxa de sobrevida média de cerca de 6 meses. Entre os cancros pancreáticos, o adenocarcinoma ductal pancreático (CP) é o tipo mais comum e é responsável por mais de 90% dos casos. Uma combinação de fatores leva ao mau prognóstico do CP, incluindo dificuldades na deteção da doença em estágio inicial, seu alto potencial metastático e sua resistência às terapias convencionais.

Identification of the metabolic alterations associated with the multidrug resistant phenotype
in cancer and their intercellular transfer mediated by extracellular vesicles

Cancer multidrug resistance (MDR) is a major cause of therapeutic failure in cancer. MDR is mainly due to the overexpression of drug efflux pumps, such as P-glycoprotein (P-gp). Besides overexpression of drug efflux pumps, other molecular mechanisms are involved in the MDR phenotype, including metabolic alterations. Indeed, recent studies showed that it is possible to revert the MDR phenotype by inhibition of glycolysis with specific modulators.

A new anti-tumor therapeutic approach with lower cardiotoxicity

Tania Martins-Marques 1,2, Maria Joao Pinho 1,2, Monica Zuzarte 1,2, Carla Oliveira 3,4,5, Paulo Pereira 6, Joost P. G. Sluijter 7,8, Celia Gomes 2,9,10, Henrique Girao 1,2*

1Institute of Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal;

2CNC.IBILI, University of Coimbra, Coimbra, Portugal; 

Extracellular Vesicles from Ovarian Carcinoma Cells Display Specific Glycosignatures

Joana Gomes 1, Patrícia Gomes-Alves 1,2, Sofia B. Carvalho 1,2, Cristina Peixoto 1,2, Paula M. Alves 1,2, Peter Altevogt 3,4 and Julia Costa 1

1 Instituto de Tecnologia Quimica e Biologica Antonio Xavier, Universidade Nova de Lisboa Av. da Republica, Oeiras 2780-157, Portugal

2 iBET, Instituto de Biologia Experimental e Tecnologica, Oeiras 2780-157, Portugal

First Iberian Meeting on Extracellular Vesicles

Atmosfera M, Porto, Portugal

 

30 September, 2015

 

See more informations here: http://www.ibmc.up.pt/IberianMeetingEVs/index.html

First Iberian Meeting on Extracellular Vesicles

Atmosfera M, Porto, Portugal

 

30 September, 2015

 

See more informations here: http://www.ibmc.up.pt/IberianMeetingEVs/index.html