Type 2 diabetes mellitus (T2DM) and breast cancer are diagnosed in the same individual more frequently than would be expected. The metabolic alterations that occur in T2DM can probably explain this link. However, to date, the studies done have not been sufficient to identify the mechanisms underlying the link between T2DM and breast cancer. It is therefore critical to identify new molecular targets that link T2DM and breast cancer and to develop new therapeutic approaches that prevent and control breast cancer initiation, promotion and progression in patients with T2DM.
A diabetes mellitus tipo 2 (DM2) e o cancro de mama são diagnosticadas no mesmo indivíduo com mais frequência do que seria esperado. As alterações metabólicas que ocorrem na DM2 podem provavelmente explicar essa ligação. No entanto, até o momento, os estudos realizados não foram suficientes para identificar os mecanismos subjacentes à ligação entre DM2 e cancro de mama.
Presently, breast cancer constitutes the most prevalent cancer in women worldwide, and about 25% of the women with breast cancer also present type 2 diabetes mellitus (T2DM).The metabolic changes characteristic of T2DM have been associated to a higher incidence and progression, worst prognontics and response to therapy. However, the association between breast cancer and type 2 diabetes are complex and remain to be fully established.
Atualmente, o cancro da mama é a neoplasia maligna mais comum entre as mulheres em todo o mundo, e cerca de 25% das mulheres que sofrem de cancro da mama têm também diagnóstico de diabetes mellitus tipo 2 (DM2). As alterações metabólicas que ocorrem na DM2 tem sido associadas à iniciação e progressão do tumor, a um pior prognóstico e a uma resposta ineficaz à terapia do cancro da mama. Contudo, a relação entre DM2 e o cancro da mama parece ser complexa e algumas questões permanecem por esclarecer.
The inflammatory status interferes with the cellular uptake of butyrate and folic acid, two nutrients with a role in colorectal cancer pathogenesis, by intestinal epitelial cells. The anti-inflammatory acetylsalicylic acid potentiates the anticarcinogenic effect of BT in Caco-2 cells by increasing its cellular uptake.
Mafalda R. Couto, M.D.1#, Pedro Gonçalves, Ph.D.1, 2#, Telmo A. Catarino, B.Sc.1, Fátima Martel, Ph.D.1
The inflammatory status interferes with the cellular uptake of butyrate and folic acid, two nutrients with a role in colorectal cancer pathogenesis, by intestinal epitelial cells. The anti-inflammatory acetylsalicylic acid potentiates the anticarcinogenic effect of BT in Caco-2 cells by increasing its cellular uptake.
Mafalda R. Couto, M.D.1#, Pedro Gonçalves, Ph.D.1, 2#, Telmo A. Catarino, B.Sc.1, Fátima Martel, Ph.D.1
