leukemia

Authors and affiliations:
Marinella N. Ghezzo (CBMR, Faro), Mónica T. Fernandes (CBMR, Faro), Ivette Pacheco-Leyva (i3S, Porto), Pedro M. Rodrigues (i3S, Porto), Rui S. Machado (CBMR, Faro), Marta A.S. Araújo (i3S, Porto), Ravi K. Kalathur (CBMR, Faro), Matthias E. Futschik (CBMR, Faro; CCMAR, Faro; ITSMED, Plymouth), Nuno L. Alves (i3S, Porto), Nuno R. dos Santos (CBMR, Faro; i3S, Porto),

Abstract:

Authors and Affiliations:

Sandrina Nóbrega-Pereira1, Francisco Caiado1, Tânia Carvalho1, Inês Matias1, Gonçalo Graça2, Luís Gafeira Gonçalves2, Bruno Silva-Santos1, Haakan Norell1 and Sérgio Dias1

Abstract:

Specific gene silencing was vectorized via gold nanoparticles to enhance the killing potential of chemotherapy against leukemia cells. By targeting the fusion oncogene BCR-ABL1 using gold nanoaprticles in chronic myeloid leukemia cells, the Portuguese researchers were capable to enhance the therapeutic efficacy of standard chemotherapy in a combined strategy that this groups has been optimizing at UCIBIO (Research Unit on Applied Molecular Biosciences), Faculdade de Ciências e Tecnologia of Universidade Nova de Lisboa.

Authors and affiliations:

Authors and Affiliations:
Mónica T. Fernandes^1,2, Marinella N. Ghezzo^1,2, André B. Silveira^3, Ravi K. Kalathur¹, Vanda Póvoa^4, Ana R. Ribeiro^5,6,7, Sílvia R. Brandalise³, Emmanuel Dejardin⁸, Nuno L. Alves^5,6, Jacques Ghysdael ^9,10,11, João T. Barata^4, José Andres Yunes^3,12, and Nuno R. dos Santos¹

In this study we identified a population of human mesenchymal stem cells capable of expanding the number of hematopoietic stem cells in laboratory. Hematopoietic stem cells reside in the bone marrow and are responsible for producing all the blood and immune cells necessary for survival. However, this group of cells is extremely rare, which limits their usage in clinical transplantations.