Gene therapy

Hepatocellular carcinoma (HCC) is one of the main causes of cancer death worldwide. Thus, the main objective of this work was to develop a new targeted lipid-polymer hybrid nanosystem that could allow the simultaneous transport of different therapeutic agents, namely antitumor drugs and nucleic acids, and their specific delivery in HCC cells. This formulation has the capability to mediate combined chemotherapy and gene therapy, as it efficiently loaded and delivered, in target cells, the drugs selumetinib and perifosine, and the PTEN transgene.

The team led by Ângela Sousa from Health Science Research Centre of the University of Beira Interior (CICS-UBI) has been focused on the development of biotechnological strategies with therapeutic potential for cervical cancer treatment. Cervical cancer is the fourth most diagnosed cancer in women, with an estimated 570 000 new cases and representing 6.6% of all female cancers in 2018 worldwide.

A equipa liderada por Ângela Sousa, do Centro de Investigação em Ciências da Saúde da Universidade da Beira Interior (CICS-UBI), tem-se focado no desenvolvimento de estratégias biotecnológicas com potencial terapêutico para o tratamento do cancro do colo do útero. O cancro do colo do útero é o quarto cancro mais frequentemente diagnosticado em mulheres, com uma estimativa de 570.000 novos casos e representando 6,6% dos casos totais de cancros femininos em todo o mundo em 2018.

Specific gene silencing was vectorized via gold nanoparticles to enhance the killing potential of chemotherapy against leukemia cells. By targeting the fusion oncogene BCR-ABL1 using gold nanoaprticles in chronic myeloid leukemia cells, the Portuguese researchers were capable to enhance the therapeutic efficacy of standard chemotherapy in a combined strategy that this groups has been optimizing at UCIBIO (Research Unit on Applied Molecular Biosciences), Faculdade de Ciências e Tecnologia of Universidade Nova de Lisboa.

Heidelberg, Germany

14 - 16 September, 2016

See more informations here: https://www.nct-heidelberg.de/das-nct/veranstaltungen/dg-gt-2016.html

Heidelberg, Germany

14 - 16 September, 2016

See more informations here: https://www.nct-heidelberg.de/das-nct/veranstaltungen/dg-gt-2016.html