Nanoparticle

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Portuguese group combine nanoparticle delivery of gene therapy and standard chemotherapy to overcome leukemia

Specific gene silencing was vectorized via gold nanoparticles to enhance the killing potential of chemotherapy against leukemia cells. By targeting the fusion oncogene BCR-ABL1 using gold nanoaprticles in chronic myeloid leukemia cells, the Portuguese researchers were capable to enhance the therapeutic efficacy of standard chemotherapy in a combined strategy that this groups has been optimizing at UCIBIO (Research Unit on Applied Molecular Biosciences), Faculdade de Ciências e Tecnologia of Universidade Nova de Lisboa.