breast cancer

Barcelona, Spain

21 - 23 March, 2018

See more informations here: https://www.ecco-org.eu/Events/EBCC11

Barcelona, Spain

21 - 23 March, 2018

See more informations here: https://www.ecco-org.eu/Events/EBCC11

Breast cancer is the most common type of cancer in women and their second leading cause of death among cancer. Fucosylated glycans are overeexpressed in breast cancer, such as sialyl-Lewis X/A (sLe^X/A), and their expression is related to increased disease progression and metastasis. These glycans in tumor circulating cells mediate binding to vascular E-selectin, initiating tumor extravasation. However, their role(s) in breast carcinogenesis is still unknown.

Authors and Affiliations:

Soraia Melo ^1,2,3, Joana Figueiredo ^1,2, Maria Sofia Fernandes ^1,2,4, Margarida Gonçalves ^1,5, Eurico Morais-de-Sá ^1,5, João Miguel Sanches ⁴ and Raquel Seruca ^1,2,3

¹ Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, 4200-135 Porto, Portugal

² Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), 4200-135 Porto, Portugal

Auditorio Rafael del Pino, Madrid, Spain

23 - 24 February, 2018

See more informations here: http://www.innovationinbreastcancer.com/

Auditorio Rafael del Pino, Madrid, Spain

23 - 24 February, 2018

See more informations here: http://www.innovationinbreastcancer.com/

Encontro Sobre Investigação em Cancro da Mama Em Portugal

«Da Investigação Básica à Clínica: análise de uma imagem com a sociedade civil»

Data: 19 de outubro

Local: Centro Académico de Medicina de Lisboa (Edifício Egas Moniz)

Participantes: Investigadores, clínicos, geneticistas, cirurgiões com trabalho desenvolvido na área do cancro da mama, associações de doentes com cancro da mama, público em geral.

The human apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional DNA repair enzyme with relevant redox signalling functions. In this paper entitled “The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel”, the quinone derivative E3330, a redox inhibitor of APE1, decreased the colony formation and chemoinvasion of docetaxel-treated MDA-MB-231 cells. In addition, E3330 as single agent significantly reduced the collective cell migration.

A endonuclease apurínica/apirimidínica 1 (APE1) é uma enzima de reparação do DNA multifuncional com funções relevantes na sinalização redox. Neste artigo intitulado “The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel”, o composto E3330, uma quinona que atua como inibidor da função redox da APE1, levou ao decréscimo da formação de colónias e da quimio-invasão de células MDA-MB-231 tratadas com docetaxel.