breast cancer

The main therapeutic strategy used in 75% of all breast cancers targets estrogen receptor α (ERα). However, the mechanisms underlying ERα therapeutic resistance are still elusive hampered by the challenges in developing suitable experimental models. In this work, a novel ex-vivo culture strategy was developed. This strategy is based on tissue microstructures encapsulation in alginate, enabling maintenance of original tissue structure, cell populations and extracellular matrix, thus recapitulating the tumoral microenvironment in which ERα signaling is sustained.

Authors and Afilliations:

Inês Gomes¹, Bernardo P. de Almeida^2,4, Sara Dâmaso³, André Mansinho^1,3, Inês Correia¹, Sara Henriques¹, Raquel Cruz-Duarte¹, Guilherme Vilhais¹, Pedro Félix¹, Patrícia Alves¹, Patrícia Corredeira¹, Nuno L. Barbosa-Morais², Luis Costa^1,3 and Sandra Casimiro¹

Ao longo dos últimos anos, esta equipa do IMM tem estudado a via RANKL-RANK, principal mecanismo regulador da remodelação óssea, e muito importante na terapêutica de doentes com metástases ósseas. Esta via de sinalização celular foi, mais recentemente, implicada na carcinogénese mamária controlada pela progesterona, estando sobretudo associada a mau prognóstico e cancro da mama triplo negativo.

Over the last 15 years my research work has been focused in understanding the molecular mechanisms that govern normal and breast cancer stem cells (CSCs). My ultimate goal has always been to translate basic discoveries to clinical applications that can in the long term directly impact on patient care and contribute to a reduction in breast cancer mortality. This work epitomizes this translational research idea because it was pivotal to establishing the grounds for a phase 2 clinical trial on metastatic breast cancer.

Cytotoxic T lymphocyte associated antigen 4 (CTLA-4) serves an important role in breast cancer progression, which has led to the development of novel immunotherapies aimed at blocking tumor immune evasion. Although feline mammary carcinoma is increasingly recognized as a valuable cancer model, no studies on CTLA-4 function had been conducted in this species. The serum CTLA-4, TNF-α and IL-6 levels of 57 female cats with mammary carcinoma were determined by ELISA, and immunohistochemistry was performed to evaluate CTLA-4 and FoxP3 expression in tumor cells and interstitial lymphocytes.

Authors and Afiliations:

Cristina Amaral, Tiago V. Augusto, Marta Almada, Sara C. Cunha, Georgina Correia-da-Silva, Natércia Teixeira

UCIBIO.REQUIMTE, Laboratório de Bioquímica, Faculdade de Farmácia, Universidade do Porto

Abstract:

Authors and Affiliations:

Ana Jacinta-Fernandes, Joana M. Xavier, Ramiro Magno, Joel G. Lage & Ana-Teresa Maia

Centre for Biomedical Research (CBMR), Algarve Biomedical Center (ABC) and Department of Biomedical Sciences and Medicine (DCBM) Universidade do Algarve, Faro 8005-139, Portugal

Abstract:

Mercure Hotel MOA Berlin, Germany

November 19-21, 2020

See more informations here: https://cobrca.org/