breast cancer

Auditorio Rafael del Pino, Madrid, Spain

17-18 February, 2017

See more informations here: http://www.doctaforum.net/eventos/innovationinbreastcancer/index.asp?idEvento=2712&idSeccion=946

The “New England Journal of Medicine” published the primary outcome results of the MINDACT study. This breakthrough clinical trial is an example of international, academic, and multi-disciplinary leadership and achievement in breast cancer research. It is also a clear illustration of an integrated public, private and patient group collaboration.

The “New England Journal of Medicine” published the primary outcome results of the MINDACT study. This breakthrough clinical trial is an example of international, academic, and multi-disciplinary leadership and achievement in breast cancer research. It is also a clear illustration of an integrated public, private and patient group collaboration.

Breast cancer is the most common type of cancer affecting women. Despite the good prognosis when detected early, the treatment of the metastatic breast cancer is still a huge challenge. The recruitment of the proton pump V-ATPase to the plasma membrane, where it contributes to the acidity of the tumor microenvironment, is a recognized feature involved in the acquisition of a metastatic phenotype in breast cancer. Therefore, inhibitors of this pump have emerged as promising anticancer drugs.

Authors and Affiliations:

Whitney S. Henry^1,*, David G. Hendrickson^2,3,*, Francisco Beca^1,3, Benjamin Glass^1,3, Marianne Lindahl-Allen^4, Lizhi He^4, Zhe Ji⁴, Kevin Struhl⁴, Andrew H. Beck^1,3, John L. Rinn^2,3 and Alex Toker¹

¹ Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

Authors and Affiliations:
Cláudia M. Deus 1,2, Teresa L. Serafim 1, Silvia Magalhães-Novais 1, Andreia Vilaça 1, Ana C. Moreira 1,2, Vilma A. Sardão 1, Susana M. Cardoso 3 and Paulo J. Oliveira 1

1 CNC - Center for Neuroscience and Cell Biology, University of Coimbra, UC Biotech Building, Biocant Park, 3060-197 Cantanhede, Portugal

2 Department of Life Sciences, School of Sciences and Technology, University of Coimbra, 3004-517 Coimbra, Portugal

Three years after a diagnosis of breast cancer, more than 40% of the patients presented at least one oncological-related neurological complication; neuropathic pain (NP) remained the major contributor to the burden of these conditions. Axillary lymph node dissection was associated with NP at one year and chemotherapy with NP at three years. Taxane-based chemotherapy was strongly associated with the prevalence of chemotherapy-induced peripheral neuropathy.

Authors and Affiliations:

Tumor heterogeneity and poor outcomes of breast cancer (BC) patients have led researchers to define new markers of disease. In recent years, microRNA expression patterns have proven to be good disease indicators. Levels of miR-203a, in particular, were shown to be altered in different types of cancer. We assessed the relationship between miR-203a expression and clinicopathological features of BC in a Portuguese cohort. The expression levels of miR-203a were analyzed in 109 formalin-fixed paraffin-embedded paired normal and tumor tissue samples.

Authors and Affiliations:

Vera A. Machado^1,2,3, Daniela Peixoto^1, Maria João Queiroz^1, Raquel Soares^2,3

¹Department/Center of Chemistry, School of Sciences, University of Minho, Braga, Portugal

²Department of Biochemistry, Faculty of Medicine, University of Porto, Portugal

³ⁱ3S Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal

Abstract:

In order to evaluate the potential therapeutic effect of exercise training in cancer-related systemic alterations, an animal model of chemically-induced mammary tumorigenesis was submitted to 35-weeks of treadmill exercise (which in humans correspond to approximately 25 years of moderate exercise). Data supports the benefits of an active lifestyle for the prevention of muscle wasting secondary to breast cancer, which occurs through the modulation of the TWEAK/NF- κB signalling pathway.

Authors and Affiliations: