ASPIC

A group of researchers from the Faculty of Health Sciences, University of Beira Interior (UBI-FCS), of the Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP) and of the School of Agriculture, Polytechnic Institute of Bragança (IPB) reported that the progression of bladder cancer from a less invasive stage to a highly invasive stage is accompanied by alterations in the metabolic phenotype of tumor cells. Since decades it is recognized that tumor cells have very specific metabolic properties associated with the malignant behavior of these cells.

Um grupo de Investigadores da Faculdade de Ciências da Saúde, Universidade da Beira Interior (FCS-UBI), do Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (ICBAS-UP) e da Escola Superior Agrária, Instituto Politécnico de Bragança (IPB) reportaram que a progressão do cancro da bexiga de um estadio menos invasivo para um estadio altamente invasivo é acompanhado por alterações no fenótipo metabólico das células tumorais.

Um grupo de investigadores do Ipatimup e do Venetian Institute of Molecular Medicine, Pádua, Itália descobriu que, a desregulação da expressão das proteínas que controlam a morfologia e a dinâmica das mitocôndrias altera as capacidades de invasão e de migração das células tumorais. Os investigadores concluíram que as alterações da morfologia mitocondrial têm um papel importante no potencial de malignidade das células tumorais. 

In this study, which included 684 patients with invasive breast carcinoma and long-term follow-up, we observed that those who presented grade 1 and grade 2 aneuploid tumours, as compared with diploid ones, had worse prognosis, either in the whole series or in early breast cancer (stages I/IIA of disease). The finding has therapeutic implications, as these patients are potential candidates to risk-adapted adjuvant therapy.

Authors and Affiliations:

Neste estudo, que incluiu 684 doentes com carcinoma invasivo da mama e “fcancro da mama, António Evaristo Pintoollow-up” de longo prazo, observámos que aquelas que apresentaram tumores aneuploides com grau 1 e grau 2 de diferenciação, quando comparados com os diplóides, tiveram pior prognóstico, tanto na série total como no cancro precoce da mama (estádios I/IIA da doença). Este achado tem implicações terapêuticas, pois estas doentes são potenciais candidatas a terapia adjuvante adaptada ao risco.

Autores e Afiliações:

An article published in Nature covers the future of postdocs and explains the failures and potential solutions of the broken postdoctoral system.

Read more here: http://www.eacr.org/news/news_detail.php?id=160

An article published in Nature covers the future of postdocs and explains the failures and potential solutions of the broken postdoctoral system.

Read more here: http://www.eacr.org/news/news_detail.php?id=160

Marriott Hotel, Regents Park, London, United Kingdom

16 - 17 September, 2015

See more informations here: http://www.smi-online.co.uk/pharmaceuticals/uk/cancer-vaccines?utm_medium=www.cancervaccinesevent.com&utm_source=P-150&utm_campaign=EACR

Marriott Hotel, Regents Park, London, United Kingdom

16 - 17 September, 2015

See more informations here: http://www.smi-online.co.uk/pharmaceuticals/uk/cancer-vaccines?utm_medium=www.cancervaccinesevent.com&utm_source=P-150&utm_campaign=EACR

Hotel Crowne Plaza, Athens, Greece

12- 13 June, 2015

See more informations here: http://www.eacr.org/user_uploads/files/meetings/SAVE%20THE%20DATE%20IMMUNOLOGY%208.pdf