Francisco Beça: Department of Pathology and Cancer Research Institute, Beth Israel Deaconess Cancer Center, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
«In many diseases, including cancer, DNA mutations create a stop codon in the wrong place. A single mutation can truncate a protein that should be 100 amino acids long to one that is just 15 long, rendering it completely useless. These are known as nonsense mutations, and they cause about 10 per cent of all genetic diseases.
It’s possible to make artificial tRNAs that recognise a premature stop codon, and instead of terminating the protein-making process, add the amino acid required to make a useful protein.
Sofia Braga, Joana Cardoso, Saudade André, Margarida Brito, Pedro Sanchez, Lurdes Orvalho, Lucília Salgado, Sérgio Dias, José B. Pereira-Leal and José Luís Passos-Coelho
Jose de Mello Saude, Lisboa, Portugal.
Abstract:
Background: The antiangiogenic drug sunitinib has never been evaluated as single agent in untreated breast cancer patients.
The EACR November image of the Month winner was sent by Patrícia Manuela Ribeiro Pereira, PhD student at the University of Aveiro, Portugal and the Faculty of Medicine at the University of Coimbra, Portugal. The image shows increased F-actin staining in human bladder cancer cells after photodynamic therapy. After plating the cancer cells, they were incubated with a photosensitizer compound and then irradiated. The cells were then stained with markers of F-actin (yellow) and nucleus (pink). F-actin, a component of cytoskeleton, has key roles in cell morphology and membrane integrity.
As recomendações para a realização de linfadenectomia axilar nos doentes com cancro da mama em estádio precoce e sujeitas a biópsia de gânglio sentinela com presença de macrometástase foram recentemente atualizadas, baseadas nos últimos estudos publicados. Mantem-se, no entanto, alguma controvérsia na decisão de não realização de cirurgia radical axilar nos doentes com gânglio sentinela positivo. O presente estudo pretendeu determinar a relação do número de cópias de mRNA da CK19 presente nos gânglios sentinela através do método OSNA com a metastização ganglionar no cancro da mama.
A administração combinada de Pd2Spm e Docetaxel desencadeia efeitos sinergéticos como antiangiogénico, mas também como anti-migratório e anti-proliferativo, mostrando o beneficio da utilização conjunta de moléculas complexas com base em metal de Paladio em regimes quimioterapêuticos.
Autores e Afiliações:
Ana L.M. Batista de Carvalho-Unidade de I&D Química-Física Molecular, Department of Chemistry, University of Coimbra, Portugal.
