Patrícia Pereira

The EACR November image of the Month winner was sent by Patrícia Manuela Ribeiro Pereira, PhD student at the University of Aveiro, Portugal and the Faculty of Medicine at the University of Coimbra, Portugal. The image shows increased F-actin staining in human bladder cancer cells after photodynamic therapy. After plating the cancer cells, they were incubated with a photosensitizer compound and then irradiated. The cells were then stained with markers of F-actin (yellow) and nucleus (pink). F-actin, a component of cytoskeleton, has key roles in cell morphology and membrane integrity.

The EACR November image of the Month winner was sent by Patrícia Manuela Ribeiro Pereira, PhD student at the University of Aveiro, Portugal and the Faculty of Medicine at the University of Coimbra, Portugal. The image shows increased F-actin staining in human bladder cancer cells after photodynamic therapy. After plating the cancer cells, they were incubated with a photosensitizer compound and then irradiated. The cells were then stained with markers of F-actin (yellow) and nucleus (pink). F-actin, a component of cytoskeleton, has key roles in cell morphology and membrane integrity.

The EACR November image of the Month winner was sent by Patrícia Manuela Ribeiro Pereira, PhD student at the University of Aveiro, Portugal and the Faculty of Medicine at the University of Coimbra, Portugal. The image shows increased F-actin staining in human bladder cancer cells after photodynamic therapy. After plating the cancer cells, they were incubated with a photosensitizer compound and then irradiated. The cells were then stained with markers of F-actin (yellow) and nucleus (pink). F-actin, a component of cytoskeleton, has key roles in cell morphology and membrane integrity.

The EACR November image of the Month winner was sent by Patrícia Manuela Ribeiro Pereira, PhD student at the University of Aveiro, Portugal and the Faculty of Medicine at the University of Coimbra, Portugal. The image shows increased F-actin staining in human bladder cancer cells after photodynamic therapy. After plating the cancer cells, they were incubated with a photosensitizer compound and then irradiated. The cells were then stained with markers of F-actin (yellow) and nucleus (pink). F-actin, a component of cytoskeleton, has key roles in cell morphology and membrane integrity.

Photodynamic therapy (PDT) is a promising method, which has been studied and applied to improve the treatment of several tumour types. PDT combines molecular oxygen, light and a photosensitizer (PS) to generate cytotoxic reactions in cancer cells. The potential of PSs conjugated with biomolecules which will be recognized by antigens or receptors overexpressed in cancer cells prompted us to synthesize and to validate the photodynamic activity of a porphyrin conjugated with human and bovine serum albumins, and the monoclonal antibody anti-CD104.