gold nanoparticles

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Image-guided nanodelivery of Pt(IV) prodrugs to GRP-receptor positive tumors

Authors and Affiliations:

Francisco Silva1,*, Carolina Mendes1, Alice D’Onofrio1, Maria Paula Cabral Campello1,2, Fernanda Marques1,2, Teresa Pinheiro2,3, Kyle Gonçalves1, Sérgio Figueiredo4,5, Lurdes Gano1,2, Mauro Ravera6, Elisabetta Gabano7, António Paulo1,2

A Step forward in Breast Cancer Research: From a Natural-Like Experimental Model to a Preliminary Photothermal Approach



Eduardo Costa 1,2,3,4, Tânia Ferreira-Gonçalves 3, Miguel Cardoso 2,5,6,7, João M. P. Coelho 8, Maria Manuela Gaspar 3, Pedro Faísca 9, Lia Ascensão 10, António S. Cabrita 2, Catarina Pinto Reis 3,8,* and Isabel V. Figueiredo 1,7,*

1 Pharmacology and Pharmaceutical Care Laboratory, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal;

A Step forward in Breast Cancer Research: From a Natural-Like Experimental Model to a Preliminary Photothermal Approach

O cancro de mama é uma das doenças com maior impacto na sociedade, não só por tratar-se de uma das patologias mais frequentemente diagnosticadas como também por ser uma das causas de morte por cancro mais comuns em mulheres, o que lhe confere elevada repercussão também a nível económico. Ao longo dos últimos anos, têm vindo a surgir novos tratamentos para cancro de mama com resultados promissores. No entanto, ainda há uma utilização preferencial de tratamentos convencionais de primeira linha ex.

Development of gold-core silica shell nanospheres coated with poly-2-ethyl-oxazoline and β-cyclodextrin aimed for cancer therapy


Catarina A. Reis a,b, Carolina F. Rodrigues a, André F. Moreira a, Telma A. Jacinto a, Paula Ferreira c e Ilídio J. Correia a,c

a CICS-UBI — Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, 6200-506 Covilhã, Portugal.

Funcionalização de nanopartículas de núcleo de ouro com um revestimento de sílica para tratamento do cancro

Os nanomateriais com um núcleo de ouro com um revestimento de sílica mesoporosa apresentam características físico-químicas compatíveis com aplicações teragnósticas, i.e., a realização em simultâneo de terapia e diagnóstico. O núcleo de ouro destas nanopartículas é compatível com a sua aplicação em imagiologia em tempo real do tecido tumoral por tomografia computorizada ou ressonância magnética, enquanto que a camada de sílica protege o núcleo de ouro da degradação induzida pela radiação e permite a encapsulação de fármacos anticancerígenos nos seus poros.

Structural characterization of functionalized gold nanoparticles for drug delivery in cancer therapy: a NMR based approach

In the present paper, we report results from a study of the structure and physicochemical properties of gold nanoparticles modified with poly(ethylene glycol) (PEG) designed for the drug delivery of the proteasome inhibitor Bortezomib (BTZ) in cancer therapy. A number of advanced analytical techniques were used to define important physicochemical characteristics such as composition, structure, surface properties, particle size and morphology.

Immunosensor for the analysis HER2 ECD

An electrochemical immunosensor for the analysis of HER2 ECD in human serum samples was developed. To achieve this goal a screen-printed carbon electrode, modified with gold nanoparticles, was used as transducer surface. A sandwich immunoassay, using two monoclonal antibodies, was employed and the detection of the antibody-antigen interaction was performed through the analysis of an enzymatic reaction product by linear sweep voltammetry. The calibration curve was established between 15 and 100 ng/mL and a limit of detection of 4.4 ng/mL was achieved.

Conjugation of gold nanoparticles and anticancer drug in pancreatic cancer cells

Authors and affiliations:

Sílvia Castro Coelho 1, Sandra Rocha 2, Petras Juzenas 3, Paula Sampaio 4, Gabriela M. Almeida 5, Filipe Santos Silva 5,6,7, Maria Carmo Pereira 1, Manuel A.N. Coelho 1

 

Treating pancreatic cancer and prostate cancer with gold nanoparticles

A multidisciplinary team of University of Porto - researchers from the Laboratório de Engenharia de Processos Ambiente e Energia  (LEPAE) of FEUP, the IBMC and IPATIMUP - together with researchers from Chalmers University of Technology (Sweden), the University of Nebraska Medical Center (USA) and Institute for Cancer Research (Norway) studied, for three years, the use of gold nanoparticles as a way to treat cancer and concluded that they increase efficiency permeation of retention and penetrability of therapeutic drugs in tissue affected by the disease.