Fátima Baltazar

Little is known about the metabolic adaptations that alter the tumour microenvironment and thus contribute to chemoresistance in urothelial bladder cancer (UBC). Here we describe that CD147 and MCT1 overexpression associates with UBC aggressiveness. Moreover, platinum-treated patients with MCT1 and CD147 positive tumours have worse prognosis. CD147 depletion reduces MCTs expression and improves cisplatin response in UBC cells. Our results provide novel insights for the involvement of CD147 and MCTs in UBC progression and chemoresistance.

Soft tissue sarcomas (STS) are a group of neoplasms, which, despite current therapeutic advances, still confer a poor outcome to half of the patients. In the present study, the expression and clinical-pathological significance of monocarboxylate transporters (MCTs), important proteins involved in cancer cells’ metabolic reprogramming, was evaluated in a series of 86 STS. Importantly, an association between MCT expression and poor prognostic variables was observed. Additionally, nuclear expression of MCT1 is described for the first time, being associated with good prognostic variables.

Os sarcomas de tecidos moles (STS) são um grupo de tumores, que, apesar dos avanços terapêuticos atuais, ainda estão associados a um mau prognóstico em metade dos pacientes. No presente estudo, a expressão e significado clinico-patológico dos transportadores de monocarboxilatos (MCTs), importantes proteínas envolvidas na reprogramação metabólica das células tumorais, foram avaliados numa série de 86 STS.

Authors and Affiliations:

Filipa Morais-Santos^1,2, Vera Miranda-Gonçalves^1,2, Sílvia Pinheiro^1,2, André F Vieira³, Joana Paredes³, Fernando C Schmitt^3,4,5,6, Fátima Baltazar^1,2,* and Céline Pinheiro^1,2,7,*

¹ School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal

² ICVS/3B’s – PT Government Associate Laboratory, Braga, Guimarães, Portugal