sarcomas

Soft tissue sarcomas (STS) are a group of neoplasms, which, despite current therapeutic advances, still confer a poor outcome to half of the patients. In the present study, the expression and clinical-pathological significance of monocarboxylate transporters (MCTs), important proteins involved in cancer cells’ metabolic reprogramming, was evaluated in a series of 86 STS. Importantly, an association between MCT expression and poor prognostic variables was observed. Additionally, nuclear expression of MCT1 is described for the first time, being associated with good prognostic variables.

Os sarcomas de tecidos moles (STS) são um grupo de tumores, que, apesar dos avanços terapêuticos atuais, ainda estão associados a um mau prognóstico em metade dos pacientes. No presente estudo, a expressão e significado clinico-patológico dos transportadores de monocarboxilatos (MCTs), importantes proteínas envolvidas na reprogramação metabólica das células tumorais, foram avaliados numa série de 86 STS.