cancer therapy

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2nd Frankfurt Cancer Conference Virtual Event, Worldwide

Virtual Event, Worldwide

 

 

24 - 26 August 2021

 

See more informations here: https://www.uct-frankfurt.de/cancerconference2021.html

2nd Frankfurt Cancer Conference Virtual Event, Worldwide

Virtual Event, Worldwide

 

24 - 26 August 2021

 

See more informations here: https://www.uct-frankfurt.de/cancerconference2021.html

Response and Resistance in Cancer Therapy Canterbury, UK 6 - 9 September 2021

Response and Resistance in Cancer Therapy Canterbury, UK 6 - 9 September 2021

Zebrafish xenografts as a fast screening platform for bevacizumab cancer therapy

Angiogenesis is a well-recognized hallmark of cancer, critically involved in tumor growth and metastatic spread. One of the key players in tumor-induced angiogenesis is VEGF-A, which is often found upregulated in many solid tumors. Bevacizumab is a humanized monoclonal antibody, whose mechanism of action is to target and neutralize human VEGF-A. Currently, bevacizumab is used in the clinic as a single agent or combined with antineoplastic drugs for several advanced cancers.

Zebrafish xenografts as a fast screening platform for bevacizumab cancer therapy

A angiogénese (formação de novos vasos sanguíneos e/ou linfáticos a partir de vasos pré-existentes) é considerada uma característica crucial no desenvolvimento tumoral, critica no crescimento do tumor e na sua disseminação metastática. Um dos fatores principais envolvidos neste processo é a molécula VEGF-A, encontrando-se frequentemente sobre-expresso em muitos tumores sólidos.

ISCaM2020 webinar series:Systemic Metabolism and Cancer 1: Cancer Therapy and Diet

Oct 20, 2020 04:00 PM London

Please click the link below to join the webinar:
https://crick.zoom.us/j/63151976897?pwd=ejNSV0dBdFF5V0J6SHF5STVRa3Y3dz09
Passcode: 680444

ISCaM2020 webinar series:Systemic Metabolism and Cancer 1: Cancer Therapy and Diet

Oct 20, 2020 04:00 PM London

Please click the link below to join the webinar:
https://crick.zoom.us/j/63151976897?pwd=ejNSV0dBdFF5V0J6SHF5STVRa3Y3dz09
Passcode: 680444

The role of RAD52 gene in genomic integrity maintenance and its potential as a therapeutic target

DNA damage signaling pathways, including DNA repair machinery, are essential to genomic stability maintenance, growth suppression of cells with genetic defects and, consequently in carcinogenesis prevention. On the other hand, the treatment outcome is highly influenced by all cellular processes involved in DNA damage reponse (DDR).

Importância do gene RAD52 na manutenção da integridade genómica e o seu potencial como alvo terapêutico

As vias de sinalização envolvidas na deteção e reparação dos danos no DNA são essenciais para a manutenção da estabilidade genómica, a supressão do crescimento de células com defeitos genéticos e, consequentemente, na prevenção da carcinogénese. Por outro lado, o outcome do tratamento é altamente influenciado por todos os processos celulares envolvidos na resposta aos danos no DNA.