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The presence of polymorphic gene variants in the human genome provides extensive genetic (and eventually phenotypic) variation affecting both normal physiological mechanisms and cancer pathogenesis. Functional genetic polymorphisms might have predictive and/or prognostic value in lung cancer, opening novel opportunities to improve prediction and guide clinical reasoning and therapeutics in lung cancer patients.

Authors and Affiliations:

Authors and Affiliations:

Vera Miranda-Gonçalves^1,2, Sara Granja^1,2, Olga Martinho^1,2,3, Mrinalini Honavar⁴,Marta Pojo^1,2, Bruno M. Costa^1,2, Manuel M. Pires⁵, Célia Pinheiro⁶, Michelle Cordeiro⁷, Gil Bebiano⁷, Paulo Costa⁸, Rui M. Reis^1,2,3, Fátima Baltazar^1,2

¹Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal

Authors and Affiliations:

Joana T. de Oliveira^1,2,3,4, Cláudia Ribeiro^1,2, Rita Barros^1,2 Catarina Gomes^1,2, Augusto J. de Matos^3,5, Celso A. Reis^1,2,3, Gerard Rutteman⁶, Fátima Gärtner^1,2,3

¹ Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal,

² Institute of Molecular Pathology and Immunology (IPATIMUP), University of Porto, Porto, Portugal,