hypoxia

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Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression

The presence of polymorphic gene variants in the human genome provides extensive genetic (and eventually phenotypic) variation affecting both normal physiological mechanisms and cancer pathogenesis. Functional genetic polymorphisms might have predictive and/or prognostic value in lung cancer, opening novel opportunities to improve prediction and guide clinical reasoning and therapeutics in lung cancer patients.

Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression

The presence of polymorphic gene variants in the human genome provides extensive genetic (and eventually phenotypic) variation affecting both normal physiological mechanisms and cancer pathogenesis. Functional genetic polymorphisms might have predictive and/or prognostic value in lung cancer, opening novel opportunities to improve prediction and guide clinical reasoning and therapeutics in lung cancer patients.

CBMR researchers take a new step to help treat more aggressive brain tumors

Investigadores do CBMR dão novo passo para ajudar a tratar tumores cerebrais mais agressivos

Patrícia Madureira e a sua equipa de investigação acabam de publicar na revista Cells um artigo científico que pode ajudar a compreender o gliobastoma multiforme, um dos tumores cerebrais mais mortíferos.

Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas

Authors and Affiliations:

Vera Miranda-Gonçalves1,2, Sara Granja1,2, Olga Martinho1,2,3, Mrinalini Honavar4,Marta Pojo1,2, Bruno M. Costa1,2, Manuel M. Pires5, Célia Pinheiro6, Michelle Cordeiro7, Gil Bebiano7, Paulo Costa8, Rui M. Reis1,2,3, Fátima Baltazar1,2

1Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal

Hypoxia Up-Regulates Galectin-3 in Mammary Tumor Progression and Metastasis

Authors and Affiliations:

Joana T. de Oliveira1,2,3,4, Cláudia Ribeiro1,2, Rita Barros1,2 Catarina Gomes1,2, Augusto J. de Matos3,5, Celso A. Reis1,2,3, Gerard Rutteman6, Fátima Gärtner1,2,3

1 Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal,

2 Institute of Molecular Pathology and Immunology (IPATIMUP), University of Porto, Porto, Portugal,