Ricardo Ribeiro

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Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression

The presence of polymorphic gene variants in the human genome provides extensive genetic (and eventually phenotypic) variation affecting both normal physiological mechanisms and cancer pathogenesis. Functional genetic polymorphisms might have predictive and/or prognostic value in lung cancer, opening novel opportunities to improve prediction and guide clinical reasoning and therapeutics in lung cancer patients.

Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression

The presence of polymorphic gene variants in the human genome provides extensive genetic (and eventually phenotypic) variation affecting both normal physiological mechanisms and cancer pathogenesis. Functional genetic polymorphisms might have predictive and/or prognostic value in lung cancer, opening novel opportunities to improve prediction and guide clinical reasoning and therapeutics in lung cancer patients.

Just another obesity paradox in Hodgkin lymphoma?

Authors and Affiliations:

Andreia Matos a, Joana Marinho-Dias b, Sofia Ramalheira c, Mário Mariz c, Maria J. Oliveira d, Manuel Bicho a, Ricardo Ribeiro a,b

a Genetics Laboratory and Environmental Health Institute, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal;

Apenas um outro paradoxo da obesidade no Linfoma Hodgkin?

Uma meta-análise contemporânea e estudos prospectivos confirmaram a associação positiva do índice de massa corporal com Linfoma Hodgkin (LH). No entanto, apesar de um aumento da evidência, o papel de adiposidade no microambiente do LH permanece por esclarecer. Sabemos que o excesso de adiposidade influencia o comportamento do tumor através de alguns mecanismos: 1) adipocinas, 2) migração de células estaminais derivadas de tecido adiposo, 3) regulação do metabolismo, e por 4) modulação da resposta imune 1.