gastric cancer

Authors and Affiliations:

Soraia Melo ^1,2,3, Joana Figueiredo ^1,2, Maria Sofia Fernandes ^1,2,4, Margarida Gonçalves ^1,5, Eurico Morais-de-Sá ^1,5, João Miguel Sanches ⁴ and Raquel Seruca ^1,2,3

¹ Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, 4200-135 Porto, Portugal

² Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), 4200-135 Porto, Portugal

Authors and Affiliations:

A collaboration between researchers from Ipatimup/i3S, INEB/i3S and Universidade de Aveiro  led to the development of a novel photoimmunoconjugate of porphyrin conjugated to trastuzumab that specifically and efficiently eliminates HER2+ gastric cancer cells following photodynamic therapy in vitro and in vivo (when compared to trastuzumab alone).

This study suggests that, in the setting of human disease, repetitive cycles of Trast:Porph photoimmunotherapy may improve treatment of HER2+ gastric cancer patients.

Authors and Affiliations:

Authors and affiliations:
Joana Ribeiro^a,b,1, Mariana Malta^b,c,1, Ana Galaghar^d, Fernanda Silva^d, Luís Pedro Afonso^d, Rui Medeiros^b,c,e,f, Hugo Sousa^b,e

¹Joint first authors

^a Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal

^b Molecular Oncology & Viral Pathology Group, IPO-Porto Research Center (CI-IPOP), Portugal

Authors and Affiliations:

Oliveira P^1,2, Carvalho J^1,2, Rocha S^1,2, Azevedo M², Reis I², Camilo V², Sousa B^1,2, Valente S^1,2, Paredes J^1,2,3, Almeida R^1,2,3, Huntsman D⁴, Oliveira C^1,2,3.

Autores e Afiliações:

Oliveira P^1,2, Carvalho J^1,2, Rocha S^1,2, Azevedo M², Reis I², Camilo V², Sousa B^1,2, Valente S^1,2, Paredes J^1,2,3, Almeida R^1,2,3, Huntsman D⁴, Oliveira C^1,2,3.

Authors and Affiliations:

The consistently high prevalence of Helicobacter pylori infection observed across age groups and studies carried out in different periods shows a large potential for decrease in the burden of gastric cancer in Portugal, and the downward trends in mortality rates may be expected to remain in the next decades.

Authors and affiliations:

Samantha Morais¹, Ana Ferro¹, Ana Bastos¹, Clara Castro^1,2, Nuno Lunet^1,3, Bárbara Peleteiro^1,3

Authors and Affiliations:
Caldeira J ¹*, Figueiredo J ²*, Brás-Pereira C ³, Carneiro P ², Moreira AM ², Pinto MT ², Relvas JB ⁴, Carneiro F ⁵, Barbosa M ⁶, Casares F ⁷, Janody F ³, Seruca R ⁸.
*The authours contributed equally