gastric cancer

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Gastric cancer mortality and prevalence of Helicobacter pylori infection in Portugal

The consistently high prevalence of Helicobacter pylori infection observed across age groups and studies carried out in different periods shows a large potential for decrease in the burden of gastric cancer in Portugal, and the downward trends in mortality rates may be expected to remain in the next decades.

 

 

Authors and affiliations:

Samantha Morais1, Ana Ferro1, Ana Bastos1, Clara Castro1,2, Nuno Lunet1,3, Bárbara Peleteiro1,3

E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade

Authors and Affiliations:
Caldeira J 1*, Figueiredo J 2*, Brás-Pereira C 3, Carneiro P 2, Moreira AM 2, Pinto MT 2, Relvas JB 4, Carneiro F 5, Barbosa M 6, Casares F 7, Janody F 3, Seruca R 8.
*The authours contributed equally

Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer

Helicobacter pylori modulates the gastric mucosa glycosylation for long term-colonization

Probing the O-glycoproteome of Gastric Cancer Cell Lines for Biomarker Discovery

Authors and Affiliations:

Diana Campos1,2, Daniela Freitas2, Joana Gomes2, Ana Magalhães2, Catharina Steentoft1, Catarina Gomes2, Malene B. Vester-Christensen1*, José Alexandre Ferreira3,4, Luis P. Afonso5, Lúcio L. Santos3, João Pinto de Sousa6, Ulla Mandel1, Henrik Clausen1, Sergey Y. Vakhrushev1, Celso A. Reis2,6,7

Worldwide Burden of Gastric Cancer Attributable to Tobacco


Bárbara Peleteiro1,2, Clara Castro1,3, Samantha Morais1, Ana Ferro1, Nuno Lunet1,2 1 EPIUnit – Institute of Public Health, University of Porto, Porto, Portugal 2 Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal 3 North Region Cancer Registry (RORENO) – Portuguese Oncology Institute, Porto, Portugal

Familial gastric cancer: genetic susceptibility, pathology, and implications for management

Authors and Affiliations:

Carla Oliveira*, Hugo Pinheiro*, Joana Figueiredo, Raquel Seruca, Fátima Carneiro

Ipatimup-Institute of Molecular Pathology and Immunology & Instituto Instituto de Investigação e Inovação em Saúde,

(C Oliveira PhD, H Pinheiro PhD, J Figueiredo PhD, R Seruca MD, Prof F Carneiro MD), and

Department of Pathology and Oncology, Faculty of Medicine (C Oliveira, R Seruca, F Carneiro),

University of Porto, Porto, Portugal; and Centro Hospitalar S João, Porto, Portugal (F Carneiro)

 

Familial gastric cancer: genetic susceptibility, pathology, and implications for management

Autores e Afiliações:

Carla Oliveira*, Hugo Pinheiro*, Joana Figueiredo, Raquel Seruca, Fátima Carneiro

Ipatimup-Institute of Molecular Pathology and Immunology & Instituto Instituto de Investigação e Inovação em Saúde,

(C Oliveira PhD, H Pinheiro PhD, J Figueiredo PhD, R Seruca MD, Prof F Carneiro MD), and

Department of Pathology and Oncology, Faculty of Medicine (C Oliveira, R Seruca, F Carneiro),

University of Porto, Porto, Portugal; and Centro Hospitalar S João, Porto, Portugal (F Carneiro)

 

Causes and consequences of microsatellite instability in gastric carcinogenesis

This review summarizes the current knowledge on the molecular mechanisms underlying the acquisition of microsatellite instability (MSI) in gastric cancer (GC) as well as on the clinic, pathologic and molecular consequences of the MSI phenotype. Additionally, current therapeutic strategies for GC and their applicability in the MSI subset are also discussed.

 

Authors and Affiliations:

Sérgia Velho*, Maria Sofia Fernandes*, Marina Leite, Ceu Figueiredo, Raquel Seruca
 * authors contributed equally to this paper

Causas e consequências da instabilidade de microsatélites na carcinogénese gástrica

Este artigo de revisão sumariza o conhecimento atual acerca dos mecanismos moleculares subjacentes à aquisição da instabilidade de microsatélites (MSI) no cancro gástrico (GC), bem como nas consequências clínicas, patológicas e moleculares do fenótipo MSI. Também são discutidas as estratégias terapêuticas no GC, e o seu potencial benefício em pacientes com fenótipo MSI.

 

Autores e Afiliações:

Sérgia Velho*, Maria Sofia Fernandes*, Marina Leite, Ceu Figueiredo, Raquel Seruca
 * authors contributed equally to this paper