gastric cancer

O cancro gástrico apresenta uma alta incidência e mortalidade, sendo necessário compreender os mecanismos moleculares subjacentes, a fim de descobrir novos biomarcadores com utilidade clinica. Este artigo de revisão resume o papel dos glicanos a as alterações da glicosilação ao longo do processo de desenvolvimento e progressão do cancro gástrico. São discutidos neste artigo as aplicações clínicas destas alterações de glicosilação. Na foto, Salomé Pinho e Celso A. Reis, investigadores do IPATIMUP.

Autores e afiliações:

The study identified proteins with abnormal glycosylation in the serum of patients with pre-neoplastic gastric lesions, indicating the possibility of non-invasive diagnosis in this context. The serum glycoproteome approach identified, among others, plasminogen as a carrier of aberrant glycoforms.

Journal:
Journal of Proteome Research

Salomé Pinho was awarded with the «Young Investigator Award» by the EACR for her contribution for the identification of a novel regulatory system of a protein that is determinant in the process of gastric cancer development and progression.

This work was recently published in Biochimica et Biophysica Acta (Pinho SS et al BBA 2012 [Epub ahead of print]) and PLoS ONE (Pinho SS et al. PLoS One. 2012;7(3):e33191) journals.

Abstract

Salomé Pinho was awarded with the “Young Investigator Award” by the EACR for her contribution for the identification of a novel regulatory system of a protein that is determinant in the process of gastric cancer development and progression.

This work was recently published in Biochimica et Biophysica Acta (Pinho SS et al BBA 2012 [Epub ahead of print]) and PLoS ONE (Pinho SS et al. PLoS One. 2012;7(3):e33191) journals.

Abstract