gastric cancer

Authors and affiliations:
Ana Ferro 1, Bárbara Peleteiro 1,2, Matteo Malvezzi 3, Cristina Bosetti 3, Paola Bertuccio 3, Fabio Levi 4, Eva Negri 3, Carlo La Vecchia 3,5 , Nuno Lunet 1,3 1-Institute of Public Health of the University of Porto (ISPUP), Rua das Taipas nº 135, 4050-600 Porto, Portugal

2-Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

This study is part of the EUR-GAST Project, established to elucidate the effects of Helicobacter pylori infection, genetic polymorphisms and environmental factors in gastric cancer etiology in European populations. The EUR-GAST Project is enclosed in a much larger European investigation (European Prospective Investigation into Cancer and Nutrition – EPIC) which is designed to investigate the relationships between diet, nutritional status, lifestyle and environmental factors and the incidence of cancer and other chronic diseases.

Escola de Ciências da Vida e da Saúde da Universidade do Minho - Campus de Gualtar - Anfiteatro A1 - Braga, Portugal

27-28 March, 2014

See more informations here: http://www.gastriccancerbraga2014.com/

Gastric cancer is one of the most prevalent and fatal in the world, especially due to its invasive nature, and the capacity to metastasize at distance, frequently without symptoms. E-cadherin is one of the most important structural molecules in the stomach, and its expression in the gastric epithelia suppresses cancer development. Carriers of mutations in the gene encoding E-cadherin have high probability of developing hereditary diffuse gastric cancer. Strategies aiming to prevent the loss of E-cadherin expression enclose high therapeutic potential for gastric cancer.

Authors and affiliations:
Ramon Andrade de Mello, MD, PhD ,1 - Serviço de Oncologia Médica - IPO do Porto 2 - Departamento de Medicina, Faculdade de Medicina da Universidade do Porto, Porto 3 - Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, Faro

The Coimbra Genomics S.A., a company dedicated to the emergent field of genomics, jointly with IPATIMUP and the Chinese organization BGI are lauching a research project aiming to understand the genetic basis of gastric carcinoma.

Authors and affiliations:

Ricardo Marcos-Pinto^1,2,3,4, Mário Dinis-Ribeiro^4,6, Fátima Carneiro^3,5, Xiaogang Wen⁵, Carlos Lopes^7,1, Céu Figueiredo^3,5, José Carlos Machado^3,5, Rui Ferreira³, Celso A. Reis^1,3,5, José Ferreira², Isabel Pedroto^1,2, Jorge Areias^1,2

1. Institute of Biomedical Sciences, University of Porto (ICBAS/UP), Porto, Portugal

Authors and affiliations:

Salomé S. Pinho1,2, Sandra Carvalho1,2, Ricardo Marcos-Pinto2,3, Ana Magalhaes1, Carla Oliveira1,4, Jianguo Gu5, Mário Dinis-Ribeiro6,7, Fátima Carneiro1,4,8, Raquel Seruca1,4, and Celso A. Reis1,2,4

1 Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Dr Roberto Frias s/n, 4200-465 Porto, Portugal

2 Institute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira n.8 228, 4050-313 Porto, Portugal

O cancro gástrico apresenta uma alta incidência e mortalidade, sendo necessário compreender os mecanismos moleculares subjacentes, a fim de descobrir novos biomarcadores com utilidade clinica. Este artigo de revisão resume o papel dos glicanos a as alterações da glicosilação ao longo do processo de desenvolvimento e progressão do cancro gástrico. São discutidos neste artigo as aplicações clínicas destas alterações de glicosilação. Na foto, Salomé Pinho e Celso A. Reis, investigadores do IPATIMUP.

Autores e afiliações:

The study identified proteins with abnormal glycosylation in the serum of patients with pre-neoplastic gastric lesions, indicating the possibility of non-invasive diagnosis in this context. The serum glycoproteome approach identified, among others, plasminogen as a carrier of aberrant glycoforms.

Journal:
Journal of Proteome Research