ASPIC

Loews Philadelphia Hotel, Philadelphia, PA, USA

4-7 September, 2014

See more informations here: http://www.esh.org/conference/esh-icmlf-16th-annual-john-goldman-conference-on-chronic-myeloid-leukemia-biology-and-therapy/

Authors and Affiliations:

Filipa Morais-Santos^1,2, Vera Miranda-Gonçalves^1,2, Sílvia Pinheiro^1,2, André F Vieira³, Joana Paredes³, Fernando C Schmitt^3,4,5,6, Fátima Baltazar^1,2,* and Céline Pinheiro^1,2,7,*

¹ School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal

² ICVS/3B’s – PT Government Associate Laboratory, Braga, Guimarães, Portugal

This work is based on using suppressor-tRNAs as a possible therapeutic tool for inherited cancer syndromes, where about 10-20% of the mutations described in are nonsense mutations. A suppressor-tRNA is a tRNA that can be altered to recognize premature stop codons (nonsense mutations), promoting their readthrough to produce full-length proteins. As a model, we used hereditary diffuse gastric cancer (HDGC), which is associated with mutations in CDH1 gene, encoding the adhesion molecule E-cadherin.

Este trabalho baseia-se na utilização de tRNAs-supressores como uma ferramenta terapêutica possível para síndromes de cancro hereditário, onde cerca de 10-20% das mutações descritas são mutações «nonsense». Um tRNA-supressor é um tRNA que pode ser alterado para reconhecer codões de paragem prematuros (mutações "nonsense"), promovendo a produção de proteínas de comprimento total. Como modelo utilizou-se o cancro gástrico difuso hereditário (HDGC), que está associado a mutações no gene CDH1, que codifica a molécula de adesão Caderina-E.

University of Sussex, United Kingdom

29 June - 2 July, 2014

See more informations here: http://www.le.ac.uk/cm/arr/home.html

University of Sussex, United Kingdom

29 June - 2 July, 2014

See more informations here: http://www.le.ac.uk/cm/arr/home.html

Barceló Malaga Hotel, Malaga, Spain

11-14 May, 2014

See more informations here: http://www.isco2014.com/welcome/

Barceló Malaga Hotel, Malaga, Spain

11-14 May, 2014

See more informations here: http://www.isco2014.com/welcome/

Fundação Champalimaud, Av. de Brasília, Lisboa, Portugal

14-15 February, 2014

See more informations here: http://fchampalimaud.org/en/newsroom/eventos/rectal-cancer-international-consensus-meeting/