biomarker

Authors and affiliations:
Rita Carvalho ^1,2,8, Liliana Santos ^3,4,5, Inês Conde^1,2,8, Ricardo Leitão^3,4,5, Hugo R. S. Ferreira^3,4,5, Célia Gomes ^3,4,5, Ana Paula Silva^3,4,5, Fernando Schmitt^2,6,10, Carina Carvalho-Maia⁷, João Lobo^7,8,9, Carmen Jerónimo^7,8, Joana Paredes^1,2,10, Ana Sofia Ribeiro^1,2

A recent study, led by Ricardo Marcos-Pinto and Ângela Fernandes, with Henrique Fernandes-Mendes as its first author, revealed associations between aberrant glycoprofiles and clinical variables. This study, conducted in the Immunology, Cancer & Glycomedicine group at i3S (led by Salomé Pinho), reveals an association between the levels of branched N-glycans in epithelial cells and factors such as age, smoking and polyp dimension, suggesting a link between these glycans and colorectal cancer progression.

The lack of a sensitive and specific biomarker for early detection of prostate cancer (PCa) is a major obstacle to the effective treatment of these patients. This study aimed to study the volatile urinary metabolic profile of PCa patients (n=58) and control individuals (cancer-free, n=60), to identify a potential panel of biomarkers for non-invasive PCa detection. The results obtained revealed a panel of biomarkers with 6 volatile compounds, which was able to identify this type of cancer with a sensitivity, specificity and accuracy of 89%, 83% and 86%, respectively.

A falta de um biomarcardor sensível e específico para a deteção precoce do cancro da próstata constitui um obstáculo ao tratamento eficaz destes doentes. Este trabalho pretendeu estudar o perfil metabólico volátil de urinas de doentes com cancro da próstata (n=58) e de indivíduos controlo (sem cancro, n=60), com o objetivo de identificar um potencial painel de biomarcadores para a deteção não invasiva do cancro da próstata.

Authors and Affiliations:

Faleiro I^1,2,3, Apolónio JD^1,2,3, Price AJ⁴, De Mello RA^1,3, Roberto VP^1,2,3, Tabori U⁵, Castelo-Branco P^1,2,3.

1. Department of Biomedical Sciences & Medicine, University of Algarve, Campus de Gambelas, Edifício 2, 8005-139 Faro, Portugal.

2. Centre for Biomedical Research (CBMR), University of Algarve, 8005-139 Faro, Portugal.

3. Algarve Biomedical Center, University of Algarve, Campus de Gambelas, 8005-139, Faro, Portugal.

Authors and Affiliations:

Autores e Afiliações:

RAMADA Hotel & Conference Center Messe München, Munich, Germany

1-2 December, 2015

See more informations here: http://www.bio-m.org/mbc/5th-munich-biomarker-conference.html