Cancer cells have increased NAD (Nicotinamide adenine dinucleotide) requirements. Thus, enzymes involved in NAD metabolism, such as NAMPT and NAPRT, are targets for the development of novel anti-cancer therapies. In this work, we show that both NAMPT and NAPRT genes are widely expressed in normal tissues but not in tumor cells, and identify some mechanisms that regulate NAPRT expression in tissues and tumors, which may have therapeutic implications.
