As sirtuinas são enzimas modificadoras das histonas que participam na regulação do metabolismo, divisão celular e envelhecimento. O seu papel na carcinogénese é complexo e está ainda a ser desvendado. Dada a associação dos carcinomas endometriais com factores hormonais, metabólicos e envelhecimento, este trabalho teve como objectivo caracterizar a expressão das sirtuinas nestes tumores.
We decided to republish in ASPIC's website the interview below:
Interview with James Allison of the MD Anderson Cancer Center, who has made key discoveries on the regulation of T cell activation and modulation. He was awarded the 2015 Lasker DeBakey Clinical Medical Research Award in honor of his discovery and subsequent development of CTLA-4–targeted monoclonal antibody therapy to unleash the immune response to cancer.
