TRIB2

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Harmine and Piperlongumine Revert TRIB2-Mediated Drug Resistance

Poor survival and treatment failure of patients with cancer are mainly due to therapy resistance. Tribbles homologue 2 (TRIB2) has recently been identified as a protein that promotes resistance to several anti-cancer drugs. In this study, RNA sequencing and bioinformatics analysis were used to characterise the impact of TRIB2 on the expression of genes and develop pharmacological strategies to revert these TRIB2-mediated changes, thereby overcoming therapy resistance.

Harmine and Piperlongumine Revert TRIB2-Mediated Drug Resistance

Poor survival and treatment failure of patients with cancer are mainly due to therapy resistance. Tribbles homologue 2 (TRIB2) has recently been identified as a protein that promotes resistance to several anti-cancer drugs. In this study, RNA sequencing and bioinformatics analysis were used to characterise the impact of TRIB2 on the expression of genes and develop pharmacological strategies to revert these TRIB2-mediated changes, thereby overcoming therapy resistance.

Research developed at the University of Algarve can help improve the effectiveness of cancer treatments


Richard Hill - DCBM/UAlg/ Brain Tumour Center (Portsmouth);

Patrícia A. Madureira - CBMR;

Bibiana Ferreira - CBMR;

Inês Baptista - CBMR;

Susana Machado - CBMR;

Laura Colaço- CBMR;

Marta dos Santos - CBMR;

Ningshu Liu - Bayer AG;

Ana Dopazo - CNIC;

Investigação desenvolvida na Universidade do Algarve pode ajudar a melhorar eficácia dos tratamentos oncológicos

Uma equipa de investigadores, liderada por Wolfgang Link, do Centro de Investigação em Biomedicina, da Universidade do Algarve, acaba de publicar, na revista Nature Communications, os resultados de uma investigação inédita na área do cancro. Reconhecendo o facto de que um número significativo de mortes se deve à resistência intrínseca ou adquirida, ao longo do tempo, à quimioterapia, os investigadores quiseram compreender de que modo as células cancerígenas se tornam resistentes às terapias convencionais.