PHLDB1

Replication of GWAS identifies RTEL1, CDKN2A/B, and PHLDB1 SNPs as risk factors in Portuguese gliomas patients

Authors and Affiliations:

Viana-Pereira M1,2, Moreno DA3, Linhares P4,5, Amorim J6, Nabiço R6, Costa S1,2, Vaz R4,5, Reis RM7,8,9.

¹School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.

² ICVS/3B's - PT Government Associate Laboratory, Minho, Portugal.

³ Barretos Cancer Hospital, Molecular Oncology Research Center, Barretos, SP, Brazil.

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CDKN2A/B

GWAS

Glioma risk

PHLDB1

Replication of GWAS identifies RTEL1, CDKN2A/B, and PHLDB1 SNPs as risk factors in Portuguese gliomas patients

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Os gliomas difusos são os tumores cerebrais primários malignos mais comuns e permanecem incuráveis, sendo necessário um maior conhecimento da etiologia destes tumores. Vários polimorfismos de nucleótido único (SNPs) rs4977756 (CDKN2A/B), rs6010620 (RTEL1), rs498872 (PHLDB1), rs2736100 (TERT) e rs4295627 (CCDC26) foram associados a uma maior suscetibilidade para desenvolver gliomas e são, por isso, potenciais biomarcadores de risco.

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PHLDB1

Replication of GWAS identifies RTEL1, CDKN2A/B, and PHLDB1 SNPs as risk factors in Portuguese gliomas patients

Replication of GWAS identifies RTEL1, CDKN2A/B, and PHLDB1 SNPs as risk factors in Portuguese gliomas patients

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