Sara Monteiro-Reis1,2*, Vera Miranda-Gonçalves1,3*, Catarina Guimarães-Teixeira1, Cláudia Martins-Lima1, João Lobo1,3,4, Diana Montezuma1, Paula C. Dias1,4, Helene Neyret-Kahn5, Isabelle Bernard-Pierrot5, Rui Henrique1,3,4, Carmen Jerónimo1,3
The mechanical properties of cells and extracellular environment, in particular their stiffness and adhesion capacity, are important in the early stages of bladder cancer initiation. A computational model, developed at the University of Coimbra, describes the different layers of the urothelium and allows to study which characteristics are most relevant to the invasive capacity of neighboring tissues by tumor cells. This work provides useful indications for the development of alternative therapeutic strategies.
Sara Monteiro-Reis (1), Ana Blanca (2), Joana Tedim-Moreira (1), Isa Carneiro (1,3), Diana Montezuma (1,3), Paula Monteiro (1,3), Jorge Oliveira (4), Luís Antunes (5), Rui Henrique (1,2,6), António Lopez-Beltran (7,8) e Carmen Jerónimo (1,6)
(1) Grupo de Epigenética e Biologia do Cancro – Centro de Investigação (CI-IPOP), Instituto Português de Oncologia do Porto Francisco Gentil EPE (IPO Porto), e Porto Comprehensive Cancer Center (P.CCC), Porto, Portugal;
Investigadores do Grupo de Epigenética e Biologia do Cancro do Centro de Investigação do IPO do Porto e da Universidade de Córdoba, em Espanha, publicaram recentemente na revista internacional Journal of Clinical Medicine os resultados de um dos seus mais recentes trabalhos, onde descrevem o desempenho de um novo teste não-invasivo que poderá ajudar na identificação de casos de cancro da bexiga numa população com outras patologias urinárias.
Bladder tumor is one of the leading causes of death, especially among men and its diagnosis is highly dependent on the interpreter’s experience of different exams. There is no doubt that the development of automatic detection systems will improve the detection accuracies of this pathology. Therefore, Nuno Freitas a Master student of Biomedical Engineering in University of Minho, oriented by Professor Carlos S.
A group of researchers from the Faculty of Health Sciences, University of Beira Interior (UBI-FCS), of the Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP) and of the School of Agriculture, Polytechnic Institute of Bragança (IPB) reported that the progression of bladder cancer from a less invasive stage to a highly invasive stage is accompanied by alterations in the metabolic phenotype of tumor cells. Since decades it is recognized that tumor cells have very specific metabolic properties associated with the malignant behavior of these cells.
