ASPIC

Authors and Affiliations:

Ana Isabel Oliveira1,2*, Ana Xavier-Magalhães^1,2*, Catarina Moreira-Barbosa³, Hugo Magalhães^1,2, Rui Henrique^3,4,5, Carmen Jerónimo^4,5, Bruno M. Costa^1,2.

¹Life and Health Sciences Research Institute (ICVS), School of Health Sciences, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal;

O objectivo deste trabalho foi avaliar o impacto dos polimorfismos de nucleótido simples (SNP – do inglês single nucleotide polymorphisms) rs920778 e rs12826786 do RNA longo não-codificante HOTAIR na susceptibilidade e prognóstico de pacientes com cancro da próstata (CaP). Neste estudo de caso-controlo, os nossos resultados mostram que não há uma associação entre as variantes polimórficas rs920778 e rs12826786 no gene HOTAIR e a susceptibilidade para o desenvolvimento de CaP.

This work reports the identification of the first small-molecule selective activator of PKCdelta with promising application in colon cancer therapy.

Considering the crucial role of p53 in cancer development and dissemination, p53-targeted therapies are amongst the most encouraging anticancer strategies. Inactivation of p53 by interaction with murine double minute (MDM)2 and MDMX is a common event in human cancers bearing wild-type (wt) p53. Consistently, simultaneous inhibition of the p53 interaction with both MDMs is crucial for full p53 reactivation in cancer.

Researchers at the Centre of Agronomic and Agro-Industrial Biotechnology of Alentejo (CEBAL) in Beja identified, in a natural population of Cynara cardunculus, two allelic variants in GAS (Germacrene A Synthase) gene sequence with significant associations between the cynaropicrin content (a lactone sesquiterpene) and the antiproliferative activity of a breast cancer cell line (MDA-MD-231), in vitro.

Investigadores do Centro de Biotecnologia Agrícola e Agro-Alimentar do Alentejo (CEBAL) em Beja identificaram, numa população natural de Cynara cardunculus, duas alterações alélicas na sequência do gene GAS (Germacrene A Synthase) com associações significativas entre o conteúdo em cinaropicrina (uma lactona sesquiterpénica) e a atividade antiproliferativa in vitro de células de cancro de mama (MDA-MD-231).

The stem cell factor (SCF) and its tyrosine kinase receptor c-KIT have been implicated in the carcinogenesis of male and female reproductive tissues. Also, several studies have reported that the tissue expression levels of SCF/c-KIT system, which is involved in the control of biological processes, such as apoptosis, cell survival, differentiation, and migration, is controlled by hormones. In this scenario, it is reasonable to question if deregulated hormone actions disturbing the SCF/c-KIT expression can be a relevant step towards carcinogenesis.