P53

Considering the crucial role of p53 in cancer development and dissemination, p53-targeted therapies are amongst the most encouraging anticancer strategies. Inactivation of p53 by interaction with murine double minute (MDM)2 and MDMX is a common event in human cancers bearing wild-type (wt) p53. Consistently, simultaneous inhibition of the p53 interaction with both MDMs is crucial for full p53 reactivation in cancer.

Authors and affiliations:
Joana Ribeiro^a,b,1, Mariana Malta^b,c,1, Ana Galaghar^d, Fernanda Silva^d, Luís Pedro Afonso^d, Rui Medeiros^b,c,e,f, Hugo Sousa^b,e

¹Joint first authors

^a Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal

^b Molecular Oncology & Viral Pathology Group, IPO-Porto Research Center (CI-IPOP), Portugal

Ionizing radiation presents itself in the form of particles (alpha particles, beta particles, protons or neutrons) or electromagnetic radiation (gamma rays and X-rays) with characteristic ionizing power and penetration. Radiotherapy is an essential tool in the treatment of cancer. We can consider various forms of radiation such as external beam radiotherapy, brachytherapy and metabolic radiotherapy. When treating cancer with ionizing radiation all cells within the irradiation volume are more or less exposed.

A radiação ionizante apresenta-se sob a forma de partículas (partículas alfa, partículas beta, protões ou neutrões) ou de radiação eletromagnética (raios gama e os raios-X) com poder ionizante e de penetração caraterísticos. A radioterapia é uma ferramenta essencial no tratamento do cancro. Podemos considerar várias formas de radioterapia como a telerradioterapia, a braquiterapia e a radioterapia metabólica. No tratamento do cancro com recurso à radiação ionizante, todas as células que se encontrem dentro do volume irradiado, são mais ou menos expostas.