ASPIC

We decided to republish in ASPIC's website the interview below:

Interview with James Allison of the MD Anderson Cancer Center, who has made key discoveries on the regulation of T cell activation and modulation. He was awarded the 2015 Lasker DeBakey Clinical Medical Research Award in honor of his discovery and subsequent development of CTLA-4–targeted monoclonal antibody therapy to unleash the immune response to cancer.

See the interview here: http://www.jci.org/videos/104

Most tumors show an increase in glucose consumption, which is metabolized resulting in lactic acid production. Consequently, the lactate formed is transported out of the tumor cells by a protein complex formed by monocarboxylate transporters (MCT) and CD147. The hyperglicolytic phenotype is characterized by the expression of the glucose transporter GLUT1, the pH regulator CAIX and lactate transporters (MCT1 and MCT4), and is associated with tumor progression and aggressiveness.

A maioria dos tumores apresenta um aumento no consumo de glucose, a qual é metabolizada resultando na produção de ácido láctico. Consequentemente, o ácido láctico formado é transportado para fora das células tumorais por um complexo de moléculas formado pelos transportadores de monocarboxilatos (MCTs) e a CD147. O fenótipo hiperglicolítico caracteriza-se pela expressão do transportador de glucose GLUT1, do regulador de pH CAIX e de transportadores de lactato (MCT1 e MCT4), e está relacionado com a progressão e agressividade tumoral.

Ionizing radiation presents itself in the form of particles (alpha particles, beta particles, protons or neutrons) or electromagnetic radiation (gamma rays and X-rays) with characteristic ionizing power and penetration. Radiotherapy is an essential tool in the treatment of cancer. We can consider various forms of radiation such as external beam radiotherapy, brachytherapy and metabolic radiotherapy. When treating cancer with ionizing radiation all cells within the irradiation volume are more or less exposed.

A radiação ionizante apresenta-se sob a forma de partículas (partículas alfa, partículas beta, protões ou neutrões) ou de radiação eletromagnética (raios gama e os raios-X) com poder ionizante e de penetração caraterísticos. A radioterapia é uma ferramenta essencial no tratamento do cancro. Podemos considerar várias formas de radioterapia como a telerradioterapia, a braquiterapia e a radioterapia metabólica. No tratamento do cancro com recurso à radiação ionizante, todas as células que se encontrem dentro do volume irradiado, são mais ou menos expostas.

Breast cancer stem cells (CSC) are believed to play a relevant role in tumor growth and relapse, metastization and active evasion to standard chemotherapy, thus representing an important tumor target. The objective of this work was to assess whether nucleolin was a receptor expressed in both breast cancer stem cells and non-stem cancer cells and whether it could be exploited to target nanoparticles-encapsulating drug combinations.

Em cancro da mama, pensa-se que existem as denominadas células estaminais cancerígenas (CEC), e que estas desempenham um papel relevante no crescimento tumoral, metastização, recorrência e resistência ativa à quimioterapia. Tais características fazem das CEC alvos terapêuticos relevantes.

Hydrogen peroxide (H₂O₂) is a well-known antiseptic used in our homes since the 1920s. But did you know that our cells produce this molecule and that at low concentrations H₂O₂ instructs our cells to do different things, acting as a signaling molecule? In fact, H₂O₂ may oxidize several cellular components including proteins, altering their function. Healthy cells use H₂O₂ to regulate several of their behaviors, including proliferation, migration, or even cell-to-cell communication.

O peróxido de hidrogénio (H₂O₂) é um anti-séptico conhecido e sobejamente utilizado desde 1920. No entanto, esta molécula é também produzida pelas células do nosso organismo e atua como molécula sinalizadora, instruindo as nossas células a alterar as suas funções. As funções celulares reguladas pelo H₂O₂ incluem a proliferação e a migração, que são particularmente relevantes no desenvolvimento do cancro.

Vienna, Austria

15 - 18 March, 2017

See more informations here: http://www.oncoconferences.ch/dynasite.cfm?dsmid=500295