Therapeutic Strategy

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A novel culture method to study breast cancer biology, in particular ERα signaling

The main therapeutic strategy used in 75% of all breast cancers targets estrogen receptor α (ERα). However, the mechanisms underlying ERα therapeutic resistance are still elusive hampered by the challenges in developing suitable experimental models. In this work, a novel ex-vivo culture strategy was developed. This strategy is based on tissue microstructures encapsulation in alginate, enabling maintenance of original tissue structure, cell populations and extracellular matrix, thus recapitulating the tumoral microenvironment in which ERα signaling is sustained.

MiR-144 overexpression as a promising therapeutic strategy to overcome glioblastoma cell invasiveness and resistance to chemotherapy

Authors and Affiliations:

Cardoso AMS1,2, Sousa M1,3, Morais CM1,3, Oancea-Castillo LR4, Régnier-Vigouroux A4, Rebelo O5, Tão H6, Barbosa M6,7, Pedroso de Lima MC1, Jurado AS1,3.

1 Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.

2 Institute for Interdisciplinary Research of the University of Coimbra, 3030-789 Coimbra, Portugal.

Modulating Autophagy as a Therapeutic Strategy for the Treatment of Paediatric High Grade Glioma

Authors and Affiliations:

Howarth A1, Madureira PA1,2, Lockwood G3, Storer LCD3, Grundy R3, Rahman R3, Pilkington GJ1, Hill R1.

1 Brain Tumour Research Centre, Institute of Biomedical and Biomolecular Sciences, IBBS, University of Portsmouth, PO1 2DT, UK

2 Centre for Biomedical Research (CBMR), University of Algarve, Campus of Gambelas, Building 8, Room 3.4, 8005-139 Faro, Portugal