autophagy

The research that was developed at Barretos Cancer Hospital (Brazil) in collaboration with the ICVS of the University of Minho, was a partnership with the company Amazônia Fitomedicamentos Ltda and revealed mechanisms of action involved in the cytotoxicity promoted by the euphol molecule, obtained from the Brazilian biodiversity in glioblastoma cells. One of these mechanisms was the induction of autophagic process, which also contributed, in parts, to potentiate the effect of the chemotherapy used in clinical practice, temozolomide.

It was published an updated critical literature review on human and yeast RAS pathways, specifically highlighting the similarities and differences between them. Moreover, it was also adressed the contribution of studying yeast RAS pathways for the understanding of human RAS and how this model organism can contribute to unveil the roles of RAS oncoproteins in the regulation of mechanisms important in the tumorigenic process, like autophagy.

Authors and affiliations:

Authors and Affiliations:

Howarth A¹, Madureira PA^1,2, Lockwood G³, Storer LCD³, Grundy R³, Rahman R³, Pilkington GJ¹, Hill R¹.

¹ Brain Tumour Research Centre, Institute of Biomedical and Biomolecular Sciences, IBBS, University of Portsmouth, PO1 2DT, UK

² Centre for Biomedical Research (CBMR), University of Algarve, Campus of Gambelas, Building 8, Room 3.4, 8005-139 Faro, Portugal

University Residential Centre and Conference Centre of Bertinoro, Bertinoro, Italy

19 - 21 October, 2017

See more informations here: http://www.iscams.org/meeting/iscam2017-4th-annual-meeting-cancer-metabolism

University Residential Centre and Conference Centre of Bertinoro, Bertinoro, Italy

19 - 21 October, 2017

See more informations here: http://www.iscams.org/meeting/iscam2017-4th-annual-meeting-cancer-metabolism

Autophagy is a catabolic process which targets cellular organelles and cytoplasmic constituents to the lysosomes for degradation, allowing the cell to maintain homeostasis and being particularly relevant during nutrient deprivation and other stresses.

A autofagia é um processo catabólico através do qual organelos celulares e constituintes do citoplasma são sinalizados para degradação no lisossoma, permitindo manter a homeostasia celular e sendo particularmente relevante em situações de falta de nutrientes ou outros tipos de stress celular.

MCE Congress and Business Center in Brussels, Belgium

26 - 29 October, 2016

See more informations here: http://www.iscams.org/meeting/iscam2016-metabolic-networks-cancer-brussels

MCE Congress and Business Center in Brussels, Belgium

26 - 29 October, 2016

See more informations here: http://www.iscams.org/meeting/iscam2016-metabolic-networks-cancer-brussels