hereditary gastric cancer

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Histopathologic analysis of total gastrectomies from asymptomatic CDH1 carriers

Within gastric cancer predisposition syndromes, Hereditary Gastric Cancer (HDGC) is caused by CDH1 germline alterations and is characterised by multigenerational diffuse gastric cancer and lobular breast cancer. Gastroscopy has limited diagnostic accuracy for the identification of early neoplastic lesions, and total gastrectomy (TG) is currently the treatment of choice for asymptomatic CDH1 carriers.

New molecular mechanism to explain cases of hereditary gastric cancer

The most common cause of Hereditary Diffuse Gastric Cancer are germline mutations of the CDH1 gene. The vast majority of CDH1 germline alterations lead to truncated forms of E-cadherin with loss of protein function.

«No Stomach for Cancer» association awards portuguese researchers

The American Association of Patients with Hereditary Gastric Cancer «No Stomach for Cancer» decided to fund with 25 thousand euros a collaborative Portuguese project from Joana Paredes and Raquel Seruca, from Ipatimup - Institute of Molecular Pathology and Immunology of the University of Porto, and Joao M. Sanches, from Institute for Systems and Robotics/Instituto Superior Técnico of University of Lisbon.