Within gastric cancer predisposition syndromes, Hereditary Gastric Cancer (HDGC) is caused by CDH1 germline alterations and is characterised by multigenerational diffuse gastric cancer and lobular breast cancer. Gastroscopy has limited diagnostic accuracy for the identification of early neoplastic lesions, and total gastrectomy (TG) is currently the treatment of choice for asymptomatic CDH1 carriers.
