Glycans

Researchers from the Glycobiology in Cancer at i3S established a unique biobank of patient-derived gastric organoids showing that these models faithfully reproduce human tissue glycosylation across stages of gastric carcinogenesis. The study further demonstrates that organoids retain tumor heterogeneity and dynamically regulate Lewis antigens, shaping Helicobacter pylori interactions.

Authors and Affiliations:

Investigadores do grupo de investigação Glycobiology in Cancer do i3S desenvolveram um biobanco de organoides gástricos derivados de pacientes, revelando que estes modelos reproduzem fielmente a glicosilação dos tecidos humanos ao longo da carcinogénese. O estudo demonstra ainda que os organoides captam a heterogeneidade tumoral e regulam dinamicamente antigénios Lewis, influenciando a interação com Helicobacter pylori.

Autores e Afiliações:

Stefan Mereiter a,b,c, Ana Magalhães a,b, Barbara Adamczyk d, Chunsheng Jin d, Andreia Almeida e,f, Lylia Drici g,Maria Ibáñez-Vea g, Catarina Gomes a,b, José A. Ferreira a,b,h, Luis P. Afonso i, Lúcio L. Santos h,j, Martin R. Larsen g, Daniel Kolarich e, Niclas G. Karlsson d, Celso A. Reis a,b,c,k

a i3S — Instituto de Investigação e Inovação em Saúde, University of Porto, Portugal

b Institute of Molecular Pathology and Immunology of the University of Porto — IPATIMUP, Porto, Portugal

Authors and Affiliations:

Pinho SS^1,2,3, Reis CA^1,2,3,4.