Associação Portuguesa de Investigação em Cancro
Gastric Cancer: adding glycosylation to the equation
Gastric Cancer: adding glycosylation to the equation
O cancro gástrico apresenta uma alta incidência e mortalidade, sendo necessário compreender os mecanismos moleculares subjacentes, a fim de descobrir novos biomarcadores com utilidade clinica. Este artigo de revisão resume o papel dos glicanos a as alterações da glicosilação ao longo do processo de desenvolvimento e progressão do cancro gástrico. São discutidos neste artigo as aplicações clínicas destas alterações de glicosilação. Na foto, Salomé Pinho e Celso A. Reis, investigadores do IPATIMUP.
Autores e afiliações:
Salomé S. Pinho1,2, Sandra Carvalho1,2, Ricardo Marcos-Pinto2,3, Ana Magalhaes1, Carla Oliveira1,4, Jianguo Gu5, Mário Dinis-Ribeiro6,7, Fátima Carneiro1,4,8, Raquel Seruca1,4, and Celso A. Reis1,2,4
1 Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Dr Roberto Frias s/n, 4200-465 Porto, Portugal
2 Institute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira n.8 228, 4050-313 Porto, Portugal
3 Department of Gastroenterology, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 4099-001 Porto, Portugal
4 Medical Faculty, University of Porto, Alameda Prof. Hernâni Monteiro 4200-319 Porto, Portugal
5 Division of Regulatory Glycobiology, Tohoku Pharmaceutical University, Sendai, Miyagi 981-8558, Japan
6 Department of Gastroenterology, Portuguese Oncology Institute of Porto, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal
7 Centre for Research in HealthTechnologies and Information Systems (CINTESIS), Medical Faculty, Alameda Prof. Hernâni Monteiro 4200-319 Porto, Portugal
8 Department of Pathology, Hospital S.João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
Abstract:
Gastric cancer has a high incidence and mortality, so there is a pressing need to understand the underlying molecular mechanisms in order to discover novel bio-markers. Glycosylation alterations are frequent during gastric carcinogenesis and cancer progression. This re-view describes the role of glycans from the initial steps of the carcinogenesis process, in which Helicobacter pylori adheres to host mucosa glycans and modulates the glycophenotype, as well as how glycans interfere with epithelial cell adhesion by modulating epithelial cadherin functionality in gastric cancer progression. Oth-er mechanisms regulating gastric cancer malignant be-havior are discussed, such as increased sialylation interfering with key signaling pathways and integrin glycosylation leading to an invasive phenotype. Applications of these glycosylation alterations in the clinical management of gastric cancer patients are discussed.
Revista:
Trends in Molecular Medicine 2013, In press
Link:
